Neurotoxic; opens the TTX-sensitive Na⁺ channel in the heart and other tissues; used for creating models of cardiac arrhythmia.

Alkaloid C₃₄H₄₇NO₁₁ from the plant Aconitum karacolicum, Ranunculaceae.

• Molecular Weight : 645.33 Da.
  
  
• Melting Point : 194-202 °C
  
  
• Solubility in : chloroform, benzene; slightly in alcohol, ether; practically not in water.
  
  
• Purity min. : 98 %
  
  
• Toxicity (LD₅₀) : mice (i.v.): 0.12 mg/kg rats (orally): 5.97 mg/kg
  
  
• Storage recommendations : stable in dry state; store at +4°C, in dark place.
  
  
• CAS Reg. No. : 302-27-2
  
  
• Merck Index 11th Ed. : 113
  
  
• Bibliography :
  
  1. Sato et al., "Pharmacological actions of Aconitine alkaloids" Tohoku J. exp. Med. 1979 128:175-187 (1979).
  2. Muroi et al., Neuropharmacology 29:567 (1990).