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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L6007 HELIOTRINE
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an alkaloid used for obtaining models of hepatitis and cirrhosis of the liver.
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Pyrrolizidine alkaloid, C16H27NO5 from plants of the Heliotropum genus, Boraginaceae.
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| PRICES |
| Quantity | US Dollars | EURO |
50 mg | 128.80 | 92.00 |
250 mg | 515.20 | 368.00 |
- Molecular Weight : 313.16 Da.
- Melting Point : 119-126 °C.
- Solubility in : soluble in chloroform; slightly turbid in water.
- Purity min. : 98 %. (TLC).
- Biological Activity : a single administration of 40 mg/100 g, s.c. on rats causes an experimental hepatitis for 20 days.
recommended doses for an experimental cirrhosis:
- 1st week: 20 mg/100 g every other day;
- 2nd week: 15 mg/100 g every other day;
- 3rd week: 10 mg/100 g every other day.
- Toxicity (LD50) : rats (male i.p.): 296 mg/kg.
rats (female i.p.): 478 mg/kg.
- Storage recommendations : Store at +4°C, in dark place.
- CAS Reg. No. : 303-33-3
- Bibliography :
- Silvingham et al., Teratogenesis, Carcinogenesis and Mutagenesis (1988). 8:205
- Bruggeman et al., "Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese Hamster cells co-cultured with chick embryo hepatocytes." Mutation Res. (1985). 142:209-212
- Schoental et al., "The effects of the pyrrolizidine alkaloid, heliotrine, and nicotinamide on the concentration of plasma insuline and blood glucose in the rat." Biochem. Soc. Trans. (1976). 4(4):649-650
- Schoental et al., Cancer Res. (1975). 35:2020-2024
- Maltsev. "Study of enzyme oxidative-reducing activity in rat liver in heliotrine chronic intoxication." Pharmacol. and Toxicol. (1971). 2:228-231
- Bull et al., "The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides." J. Path. Bact. (1959). 78:483-502
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