a substance which inhibits cholinesterases reversibly.

Alkaloid C₁₁H₁₂N₂.HCl .2H₂O from plants of the Zygophyllaceae family

• Molecular Weight : 244.7 Da.
  
  
• Melting Point : 255-256 °C.
  
  
• Solubility in : dissolves in water, in alcohol; slightly in chloroform; not in acetone.
  
  
• Purity min. : 99.5% (HPLC).
  
  
• Biological Activity : inhibits butyrylcholinesterase more strongly than acetylcholinesterase. Desoxypeganine hydrochloride inhibits also monoamine oxydases. Because of the reciprocal interaction, a functional balance appears between the cholinergic and adrenergic activities which reduces the toxicity of this substance as regards its anticholinesterase activity. Desoxypeganine hydrochloride crosses easily the blood-brain barrier.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 56 mg/kg. mice (orally): 98 mg/kg.
  
  
• Storage recommendations : stable in dry state; store at +4°C, in dark place.
  
  
• CAS Reg. No. : 61939-05-7
  
  
• Bibliography :
  
  1. S.Yu. Yunusov, Alkaloids, FAN, p. 242. Tashkent (1983) (Russian).
  2. N. Tulyaganov and al., Pharmacologia i toxicologia 3:37 (1986) (Russian).