Selective blocker of the TTX-sensitive Na⁺ channels, without influence on the activation threshold of Na⁺ channels; potent antiarrhythmic; the activity of Lappaconitine hydrobromide is independent of the potential level and of the stimulus intensity; presents weak affinity at brain aBungarotoxin-sensitive nAChR.

C₁₈ diterpenoid alkaloid C₃₂H₄₄N₂O₈.HBr from plants of the Aconitum genus, Ranunculaceae.

• Molecular Weight : 665.6 Da.
  
  
• Solubility in : water, ethanol, chloroform; not well in methanol.
  
  
• Purity min. : 96%.
  
  
• Toxicity (LD₅₀) : mice i.v.: 6.1 mg/kg. mice orally : 25.0 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 97792-45-5
  
  
• Merck Index 11th Ed. : 5237
  
  
• Bibliography :
  
  1. Valeev et al., "Allapinine influence on sodium currents of isolated neurons of trigeminal ganglion and cardiomyocytes of rats." Neurophysiologia (1990) (Russian). 22(2):201-206