LAPPACONITINE HYDROBROMIDE - LATOXAN Technical Data Sheet
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ION CHANNEL and RECEPTOR LIGANDS
TOXINS & ALKALOIDS

 
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L6010 LAPPACONITINE HYDROBROMIDE
( ALLAPININE )

Selective blocker of the TTX-sensitive Na+ channels, without influence on the activation threshold of Na+ channels; potent antiarrhythmic; the activity of Lappaconitine hydrobromide is independent of the potential level and of the stimulus intensity; presents weak affinity at brain aBungarotoxin-sensitive nAChR.

  1. see annexed table : Evaluation of 8 Alkaloids for Activity at Neuronal...

C18 diterpenoid alkaloid C32H44N2O8.HBr from plants of the Aconitum genus, Ranunculaceae.


PRICES
QuantityUS DollarsEURO
10 mg 159.60 114.00
50 mg 638.40 456.00


  • Molecular Weight : 665.6 Da.

  • Solubility in : water, ethanol, chloroform; not well in methanol.

  • Purity min. : 96%.

  • Toxicity (LD50) : mice i.v.: 6.1 mg/kg. mice orally : 25.0 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place.

  • CAS Reg. No. : 97792-45-5

  • Merck Index 11th Ed. : 5237

  • Bibliography :
    1. Valeev et al., "Allapinine influence on sodium currents of isolated neurons of trigeminal ganglion and cardiomyocytes of rats." Neurophysiologia (1990) (Russian). 22(2):201-206



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan