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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L6011 LYCORINE HYDROCHLORIDE
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a selective inhibitor of Peptidyl Transferase Center (PTC): inhibits protein synthesis; emetic; enhances bronchial gland secretion and possesses relaxing effect on bronchial muscles; probably dopaminergic receptor agonist.
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Phenantridine alkaloid C16H17NO4.HCl from plants of the Amaryllidaceae family.
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| PRICES |
| Quantity | US Dollars | EURO |
20 mg | 77.00 | 55.00 |
100 mg | 308.00 | 220.00 |
- Molecular Weight : 323.77 Da.
- Melting Point : 210-212 °C.
- Solubility in : slightly in 95% alcohol; not well in water; not in chloroform.
- Purity min. : 98 %. (IR, mass spectrometry, NMR, non aqueous titration)
- Physical Form : fine crystal powder.
- Biological Activity : one of the most active inhibitors of protein synthesis catalyzed by eucaryotic ribosomes among this group of Amaryllidaceae alkaloids.
prevents the transfer of the N-acetylleucyl residue from 3'-terminal fragments of AcLeu-tRNA onto puromycin [3-4].
binds to 60S ribosomal subunit isolated from wheat germ with Ka = 8.65x102 M-1. Changes their conformation in the PTC region. These events can result in blocking the oligonucleotide model donor adsorption [1].
the emetic effect on dogs starts at the dose of 0.5 mg/kg s.c.
- Toxicity (LD50) : mice (orally): 180 mg/kg
mice (s.c.): 108 mg/kg
- Storage recommendations : Stable in dry state, store at +4°C, in dark place.Solution for use: 10-4 - 10-2 g/ml. For experiment in vivo:
- as an emetic: 0.1 - 1.0 mg/kg s.c.
- as a cholinesterase inhibitor: 5 - 10 mg/kg s.c.
- CAS Reg. No. : 2188-68-3
- Bibliography :
- Kukhanova M. et al., "Peptidyltransferase center of ribosomes. On the mechanism of action of alkaloid Lycorine." FEBS Letters (1983). 160(1,2):129-133
- Yunusov.S.Y., Alkaloids. FAN, Tashkent (1983) (Russian).
- Carrasco L. et al., FEBS Letters (1975). 52:236-239
- Jimenez A. et al., Biochim. Biophys. Acta (1976). 425:342-348
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