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Home Page > Alphabetical Index > LYCORINE HCl

LYCORINE HCl Prod. No L6011 - CAS # 2188-68-3
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Product Name LYCORINE HCl
Product Code L6011
LYCORINE HCl

C16H17NO4.HCl
Molecular Formula C16H17NO4.HCl
Description

a selective inhibitor of Peptidyl Transferase Center (PTC): inhibits protein synthesis; emetic; enhances bronchial gland secretion and possesses relaxing effect on bronchial muscles; probably dopaminergic receptor agonist.

Phenantridine alkaloid C16H17NO4.HCl ‚ from plants of the Amaryllidaceae family.
 
Biological Activity

one of the most active inhibitors of protein synthesis catalyzed by eucaryotic ribosomes among this group of Amaryllidaceae alkaloids.
prevents the transfer of the N-acetylleucyl residue from 3'-terminal fragments of AcLeu-tRNA onto puromycin [3-4].
binds to 60S ribosomal subunit isolated from wheat germ with Ka = 8.65x102 M-1. Changes their conformation in the PTC region. These events can result in blocking the oligonucleotide model donor adsorption [1].
the emetic effect on dogs starts at the dose of 0.5 mg/kg s.c.
 
Chemical and Physical Properties
 
CAS No. 2188-68-3 Molecular Weight 323.77 Da.
RTECS Physical Form fine crystal powder.
Merck Index No (13th Ed.) Melting point 210-212 °C.
PubChem SID Solubility slightly in 95% alcohol; not well in water; not in chloroform.
Purity 98 %. (IR‚ mass spectrometry‚ NMR‚ non aqueous titration) Optical Activity [a]D +38 ± 4° (c = 1;water)
Toxicity (LD50) mice (orally): 180 mg/kg
mice (s.c.): 108 mg/kg
Chemical Names
Storage & Reconstitution Recommendations Stable in dry state‚ store at +4°C‚ in dark place.Solution for use: 10-4 - 10-2 g/ml. For experiment in vivo:
- as an emetic: 0.1 - 1.0 mg/kg s.c.
- as a cholinesterase inhibitor: 5 - 10 mg/kg s.c.
Safety Recommendations
 
Bibliographic References
  1. Kukhanova M. et al., "Peptidyltransferase center of ribosomes. On the mechanism of action of alkaloid Lycorine." FEBS Letters (1983). 160(1,2):129-133
  2. Yunusov.S.Y., Alkaloids. FAN, Tashkent (1983) (Russian).
  3. Carrasco L. et al., FEBS Letters (1975). 52:236-239
  4. Jimenez A. et al., Biochim. Biophys. Acta (1976). 425:342-348
 
Prices
Code
Quantity
US $
€uro
L6011
20 mg
77.00
55.00
100 mg
308.00
220.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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