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Home Page > Alphabetical Index > TETRAHYDROBERBERINE ((d‚l)-)

TETRAHYDROBERBERINE ((d‚l)-) Prod. No L6016 - CAS # 522-97-4
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Product Name TETRAHYDROBERBERINE ((d‚l)-)
(Syn.: Canadine)
Product Code L6016
TETRAHYDROBERBERINE ((d‚l)-)

C20H21NO4
Molecular Formula C20H21NO4
Description

a D1/D2 dopaminergic receptors antagonist with sedative tranquillizing action; as a Tetrahydropalmatine analog‚ probably blocks voltage dependent calcium channels.

Berberis diisoquinoline alkaloid C20H21NO4 ‚ synthetic
 
Biological Activity

Tetrahydroberberine presents a sedative/tranquillizing effect‚ probably due to its blocking action on D1/D2 receptors in brain. In contrast with the other non specific D1/D2 receptors blockers‚ Tetrahydroberberine does not cause catalepsy. (Niwa et al.‚ 1991); Tetrahydroberberine is probably a calcium antagonist.
 
Chemical and Physical Properties
 
CAS No. 522-97-4 Molecular Weight 339.38 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 1744 Melting point 168-169°C.
PubChem SID Solubility chloroform; not well in ethanol and methanol.
Purity 95 % (TLC‚ mass-spectrometry). Optical Activity
Toxicity (LD50) mice (orally): 935 mg/kg (880-990).

mice (s.c.): 750 mg/kg (685-819).

mice (i.v.): 95 mg/kg (80-112).
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Niwa et al., "Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate". Parmacology (1991). 43:329-336
  2. Yamahara "Behavioral pharmacology of berberine-type alkaloids. II. Central depressant effect of tetrahydroberberine (THB) and its related compounds." Folia Pharmacol. Jap. (1976). 72:909-927
 
Prices
Code
Quantity
US $
€uro
L6016
20 mg
130.20
93.00
100 mg
520.80
372.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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