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Home Page > Alphabetical Index > ERYSIMOSIDE

ERYSIMOSIDE Prod. No L6021 - CAS # 7082-34-0
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Product Name ERYSIMOSIDE
Product Code L6021
ERYSIMOSIDE

C35H52O14.H2O
Molecular Formula C35H52O14.H2O
Description

an inhibitor of Na+/K+-ATPase; cardiotonic.

Cardenolide (cardiac glycoside) C35H52O14.H2O ‚ from plants of the Erysimum genus‚ Cruciferae.
 
Biological Activity

Erysimoside is a specific inhibitor of Na+/K+ ATPase‚ which acts selectively on the heart and presents a diastolic positive inotropic and tonotropic action. It is less toxic than Erysimin or Digitoxin.
IC50 (heart) = 0.19 µM (Ouabaine: 0.26 µM);
IC50 (kidney) = 0.30 µM (Ouabaine: 1.00 µM).
 
Chemical and Physical Properties
 
CAS No. 7082-34-0 Molecular Weight 714.82 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 239-241 °C.
PubChem SID 166060 Solubility well in water‚ methanol and ethanol.
Purity 97 % (TLC‚ mass-spectrometry). Optical Activity [a]D + 22.5° ± 2.5° (5% methanol).
Toxicity (LD50) cats (i.v.): 0.11 - 0.14 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Kowalewski et al., Helv. Chim. Acta (1960). 43:957:1280
  2. Beer et al., "The thermodynamic essence of the reversible inactivation of Na+/K+-transporting ATPase by various digitalis derivatives is relaxation of enzyme conformational energy." Biochim. Biophys. Acta (1988). 937:335-346
 
Prices
Code
Quantity
US $
€uro
L6021
5 mg
65.80
47.00
25 mg
263.20
188.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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