a CNS stimulant; convulsant; probably Glycinergic antagonist.

Indole alkaloid C₁₉H₂₀N₂O from the plant Vinca erecta, Apocynaceae.

• Molecular Weight : 292 Da.
  
  
• Melting Point : 187-188 °C.
  
  
• Solubility in : chloroform; less in alcohol.
  
  
• Purity min. : 97 % (TLC).
  
  
• Biological Activity : facilitates the neurotransmission at synapses between neurons of the spinal cord. Low concentrations excite the CNS, and toxic concentrations cause convulsions leading to mortality. The convulsions look like those caused by Strychnine, but Norfluorocurarine is 10 times as potent as Strychnine.
  
  
• Toxicity (LD₅₀) : ( LD50 using a 0.1% solution): mice (i.v.): 5.6 mg/kg; mice (s.c.): 14 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 6880-54-2
  
  
• Bibliography :
  
  1. Sultanov et al., "Pharmacology of alkaloids from Vinca erecta Rgl. et Schmalh." Second Indo-Soviet Symposium on the Chemistry of Natural Products Including Pharmacology. New-Delhi (1970) . 38-39
  2. Boit, Ergebnisse der Alkaloid-Chemie bis 1960. Akademie-Verlag, Berlin (1960). p. 623