a short-acting selective sympathetic ganglioblocker, with a weak antagonist activity on the nicotinic receptor at the neuromuscular junction; hypotensive.

Alkaloid C₂₀H₂₃ClN₂O derivative of Norfluorocurarine from the plant Vinca erecta, Apocynaceae.

• Molecular Weight : 342.5 Da.
  
  
• Melting Point : 266-267 °C.
  
  
• Solubility in : well in water and methanol.
  
  
• Purity min. : 97 % (TLC, mass-spectrometry).
  
  
• Biological Activity : Fluorocurarine chloride is a short-acting ganglioblocker. 0.02-0.2 mg/kg selectively block sympathetic ganglia with an activity 6 times as potent as that of arfonad; 2-3 mg/kg block the neuromuscular conductivity by non-depolarizing action. Fluorocurarine chloride is not toxic for the cardiovascular system; it lowers the blood pressure and has no influence on M-cholinergic and histaminergic receptors.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 4.6 mg/kg (solution 0.1%). mice (s.c.): 102.5 mg/kg (solution (1%).
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 22273-09-2
  
  
• Bibliography :
  
  1. Vakhabov. Pharmacol. Toxicol. 1:18 (1976) (Russian).