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Home Page > Alphabetical Index > FLUOROCURARINE CHLORIDE

FLUOROCURARINE CHLORIDE Prod. No L6026 - CAS # 22273-09-2
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Product Name FLUOROCURARINE CHLORIDE
(Syn.: Vincanine chlormethylate)
Product Code L6026
FLUOROCURARINE CHLORIDE

C20H23ClN2O
Molecular Formula C20H23ClN2O
Description

a short-acting selective sympathetic ganglioblocker‚ with a weak antagonist activity on the nicotinic receptor at the neuromuscular junction; hypotensive.

Alkaloid C20H23ClN2O derivative of Norfluorocurarine from the plant Vinca erecta‚ Apocynaceae.
 
Biological Activity

Fluorocurarine chloride is a short-acting ganglioblocker.
0.02-0.2 mg/kg selectively block sympathetic ganglia with an activity 6 times as potent as that of arfonad;
2-3 mg/kg block the neuromuscular conductivity by non-depolarizing action.
Fluorocurarine chloride is not toxic for the cardiovascular system; it lowers the blood pressure and has no influence on M-cholinergic and histaminergic receptors.
 
Chemical and Physical Properties
 
CAS No. 22273-09-2 Molecular Weight 342.5 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 266-267 °C.
PubChem SID Solubility well in water and methanol.
Purity 97 % (TLC‚ mass-spectrometry). Optical Activity
Toxicity (LD50) mice (i.v.): 4.6 mg/kg (solution 0.1%).
mice (s.c.): 102.5 mg/kg (solution (1%).
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Vakhabov. Pharmacol. Toxicol. 1:18 (1976) (Russian).
 
Prices
Code
Quantity
US $
€uro
L6026
20 mg
134.40
96.00
100 mg
537.60
384.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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