a CNS stimulant, convulsant and hypertensive.

Alkaloid C₁₇H₁₃NO₃ from plants of the Rutaceae family.

• Molecular Weight : 279 Da.
  
  
• Melting Point : 187-188 °C.
  
  
• Solubility in : well in chloroform and hot alcohol.
  
  
• Purity min. : 96 % (TLC, mass spectrometry).
  
  
• Biological Activity : CNS stimulant; increases breath rhythm, reflex excitability and intensifies clinical cramps (tonic cramps); 1-10 mg/kg increase arterial pressure by 5-20 mm Hg during 2-30 mn; 1-3-5 mg/kg, on cats and dogs under anaesthesia, increase breath rhythm, which remains after decerebration, total excision of cerebellum and carotide ganglion block; 3 mg/kg and more, increase electric activity in the cortex and subcortex formations; 5 mg/kg, remove completely the action of Thiopental sodium, Barbamil, Aminazine and Morphine on the bioelectrical activity of rabbit brain; 0.5-3mg/kg facilitate the conductivity of electric impulse in the downward activating system and stimulates the respiratory system of the reticulum formation of the caudal part of cat brain.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 363.5 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 485-61-0
  
  
• Bibliography :
  
  1. Ishmukamedov et al., "Foliosine influence on respiratory zones of reticular formation of caudal part of the brain." Pharmacology of alkaloids and glycosides. (1967) Tashkent p. 26-29 (Russian).
  2. Nasyrov et al., "EEG analysis of Foliosine alkaloid effect on the CNS." Rpts. Acad. Sci. UzSSR 2:51-53 (1968) (Russian).