a CNS stimulant‚ convulsant and hypertensive.

Alkaloid C₁₇H₁₃NO₃ ‚ from plants of the Rutaceae family.

CNS stimulant; increases breath rhythm‚ reflex excitability and intensifies clinical cramps (tonic cramps);
1-10 mg/kg increase arterial pressure by 5-20 mm Hg during 2-30 mn;
1-3-5 mg/kg‚ on cats and dogs under anaesthesia‚ increase breath rhythm‚ which remains after decerebration‚ total excision of cerebellum and carotide ganglion block;
3 mg/kg and more‚ increase electric activity in the cortex and subcortex formations;
5 mg/kg‚ remove completely the action of Thiopental sodium‚ Barbamil‚ Aminazine and Morphine on the bioelectrical activity of rabbit brain;
0.5-3mg/kg facilitate the conductivity of electric impulse in the downward activating system and stimulates the respiratory system of the reticulum formation of the caudal part of cat brain.

1. Ishmukamedov et al., "Foliosine influence on respiratory zones of reticular formation of caudal part of the brain." Pharmacology of alkaloids and glycosides. (1967) Tashkent p. 26-29 (Russian).
2. Nasyrov et al., "EEG analysis of Foliosine alkaloid effect on the CNS." Rpts. Acad. Sci. UzSSR 2:51-53 (1968) (Russian).