probably calcium antagonist; platelet aggregation inhibitor; anti-inflammatory; analgesic.

Bisbenzylisoquinoline alkaloid C₃₉H₄₄N₂O₇ from plants of the Thalictrum genus, Ranunculaceae.

• Molecular Weight : 652 Da.
  
  
• Melting Point : 156-157 °C.
  
  
• Solubility in : chloroform; not well in ethanol, methanol.
  
  
• Purity min. : 95 % (TLC, mass-spectrometry).
  
  
• Biological Activity : Inhibits rat platelet aggregation induced by collagen, ADP, A23187 and arachidonic acid and inhibits A23187-induced concentration increase of cytosolic free calcium in human platelet. Antipyretic, anti-inflammatory and analgesic.
  
  
• Toxicity (LD₅₀) : mice (s.c.): 282 mg/kg. rats (s.c.): 175 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 6681-13-6
  
  
• Bibliography :
  
  1. Shu-Hua Chen et al., "Calcium antagonists from traditional Chinese herbs." Drug News and Perspectives (1990). 3(7):425-428
  2. M. Shamma et al., Chem. Comm., (1966). 7
  3. Sadritdinov, "Alkaloid inflammatory effects of Hernandezine and some of its action mechanisms." Alkaloid and heart glycoside pharmacology, Tashkent, (1971) (Russian). 117-120