HERNANDEZINE - LATOXAN Technical Data Sheet
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L6030 HERNANDEZINE

probably calcium antagonist; platelet aggregation inhibitor; anti-inflammatory; analgesic.

Bisbenzylisoquinoline alkaloid C39H44N2O7 from plants of the Thalictrum genus, Ranunculaceae.


PRICES
QuantityUS DollarsEURO
5 mg 89.60 64.00
25 mg 358.40 256.00


  • Molecular Weight : 652 Da.

  • Melting Point : 156-157 °C.

  • Solubility in : chloroform; not well in ethanol, methanol.

  • Purity min. : 95 % (TLC, mass-spectrometry).

  • Biological Activity : Inhibits rat platelet aggregation induced by collagen, ADP, A23187 and arachidonic acid and inhibits A23187-induced concentration increase of cytosolic free calcium in human platelet. Antipyretic, anti-inflammatory and analgesic.

  • Toxicity (LD50) : mice (s.c.): 282 mg/kg. rats (s.c.): 175 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place.

  • CAS Reg. No. : 6681-13-6

  • Bibliography :
    1. Shu-Hua Chen et al., "Calcium antagonists from traditional Chinese herbs." Drug News and Perspectives (1990). 3(7):425-428
    2. M. Shamma et al., Chem. Comm., (1966). 7
    3. Sadritdinov, "Alkaloid inflammatory effects of Hernandezine and some of its action mechanisms." Alkaloid and heart glycoside pharmacology, Tashkent, (1971) (Russian). 117-120



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan