a potent GABA_A competitive antagonist, twice as potent as Bicuculline.

Phthalide isoquinoline alkaloid C₂₁H₂₁NO₆ from the plant Corydalis pseudoadunca, Fumariaceae.

• Molecular Weight : 383.39 Da.
  
  
• Melting Point : 125-132 °C.
  
  
• Solubility in : chloroform; slightly in methanol and ethanol; practically not in water.
  
  
• Purity min. : 98 %.
  
  
• Biological Activity : d-beta Hydrastine acts as a competitive antagonist of GABA; GABA-activated currents in rat isolated neurons are strongly and reversibly blocked by an external application of d-beta Hydrastine and its effect is similar but twice as potent as that of d-Bicuculline.
  
  
• Toxicity (LD₅₀) : mice(i.v.): 0.102 mg/kg. mice (s.c.): 0.96 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 118-08-1
  
  
• Bibliography :
  
  1. Chernevskaja et al., "Inhibitions of the GABA-induced currents of rat neurons by the alkaloid isocoryne from the plant Corydalis pseudoadunca." Toxicon (1990). 28(6):727-730