ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS
L6031 d-bHYDRASTINE
( Isocoryne )
a potent GABAA competitive antagonist, twice as potent as Bicuculline.
Phthalide isoquinoline alkaloid C21H21NO6 from the plant Corydalis pseudoadunca, Fumariaceae.
PRICES
Quantity
US Dollars
EURO
50 mg
96.60
69.00
250 mg
386.40
276.00
Molecular Weight : 383.39 Da.
Melting Point : 125-132 °C.
Solubility in : chloroform; slightly in methanol and ethanol; practically not in water.
Purity min. : 98 %.
Biological Activity : d-beta Hydrastine acts as a competitive antagonist of GABA; GABA-activated currents in rat isolated neurons are strongly and reversibly blocked by an external application of d-beta Hydrastine and its effect is similar but twice as potent as that of d-Bicuculline.
Storage recommendations : Store at +4°C, in dark place.
CAS Reg. No. : 118-08-1
Bibliography :
Chernevskaja et al., "Inhibitions of the GABA-induced currents of rat neurons by the alkaloid isocoryne from the plant Corydalis pseudoadunca." Toxicon (1990). 28(6):727-730