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Home Page > Alphabetical Index > HYDRASTINE (Isocoryne) (d-β-)
| HYDRASTINE (Isocoryne) (d-β-) Prod. No L6031 - CAS # 118-08-1 |
| Product Name | HYDRASTINE (Isocoryne) (d-β-) (Syn.: Isocoryne) |
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| Product Code | L6031 |  C21H21NO6 |
| Molecular Formula | C21H21NO6 | |
| Description | a potent GABAA competitive antagonist‚ twice as potent as Bicuculline. Phthalide isoquinoline alkaloid C21H21NO6 ‚ from the plant Corydalis pseudoadunca‚ Fumariaceae. |
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| Biological Activity | d-beta Hydrastine acts as a competitive antagonist of GABA; GABA-activated currents in rat isolated neurons are strongly and reversibly blocked by an external application of d-beta Hydrastine and its effect is similar but twice as potent as that of d-Bicuculline. |
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| Chemical and Physical Properties | |||||||||||||||
| CAS No. | 118-08-1 | Molecular Weight | 383.39 Da. | ||||||||||||
| RTECS | Physical Form | ||||||||||||||
| Merck Index No (13th Ed.) | Melting point | 125-132 °C. | |||||||||||||
| PubChem SID | Solubility | chloroform; slightly in methanol and ethanol; practically not in water. | |||||||||||||
| Purity | 98 %. | Optical Activity | |||||||||||||
| Toxicity (LD50) | mice(i.v.): 0.102 mg/kg. mice (s.c.): 0.96 mg/kg. |
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| Storage & Reconstitution Recommendations | Store at +4°C‚ in dark place. | ||||||||||||||
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| External Links |  PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID |
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