 |


ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

|
|

| | L6032 3-aChloro-IMPERIALINE
|

| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 207.20 | 148.00 |
5 x 1 mg | 828.80 | 592.00 |
- Molecular Weight : 447 Da.
- Melting Point : 215-220 °C.
- Solubility in : chloroform; not well in acetone, methanol, ethanol, water.
- Purity min. : 97% (TLC).
- Biological Activity : 3-alpha-Chloro-Imperialine, long-acting cholinoblocker of M2 receptors, blocks M2 receptors in the heart at 5 µg/kg (i.v.) and the action develops gradually.
3-alpha-Chloro-Imperialine activity is more than 10 times higher than that of Imperialine and is specially high in the brain.
- Toxicity (LD50) : mice (i.v.): 52 mg/kg.
- Storage recommendations : Store at +4°C, in dark place.
- CAS Reg. No. : 153720-48-0
- Merck Index 11th Ed. : 4840
- Bibliography :
- Eglen et al., "Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro." Naunyn-Schmiedeberg’s Arch. Pharmacol. (1992) 346:144-151
- on 3-b-Bromo-Imperialine: Mirzaev, unbublished results.
|
|
Latoxan - 20, Rue Léon Blum - F-26000 VALENCE - France Phone: +33.4.75.41.91.91 - Fax: +33.4.75.41.91.99
contact@latoxan.com
For Research Purposes Only - Not for Human Use. |
Revised : 26/04/2007 10:27 - Copyright © Latoxan |
|