a potent long-acting selective M₂ muscarinic receptor antagonist, with a strong activity on the brain.

Cervane alkaloid C₂₇H₄₂CINO₂ derivative of Imperialine from the plant Petilium eduardi.

• Molecular Weight : 447 Da.
  
  
• Melting Point : 215-220 °C.
  
  
• Solubility in : chloroform; not well in acetone, methanol, ethanol, water.
  
  
• Purity min. : 97% (TLC).
  
  
• Biological Activity : 3-alpha-Chloro-Imperialine, long-acting cholinoblocker of M₂ receptors, blocks M₂ receptors in the heart at 5 µg/kg (i.v.) and the action develops gradually. 3-alpha-Chloro-Imperialine activity is more than 10 times higher than that of Imperialine and is specially high in the brain.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 52 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 153720-48-0
  
  
• Merck Index 11th Ed. : 4840
  
  
• Bibliography :
  
  1. Eglen et al., "Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro." Naunyn-Schmiedeberg’s Arch. Pharmacol. (1992) 346:144-151
  2. on 3-b-Bromo-Imperialine: Mirzaev, unbublished results.