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Home Page > Alphabetical Index > IMPERIALINE (3-β-Chloro-)

IMPERIALINE (3-β-Chloro-) Prod. No L6033 - CAS # 153720-49-1
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Product Name IMPERIALINE (3-β-Chloro-)
Product Code L6033
IMPERIALINE (3-β-Chloro-)

C27H42CINO2
Molecular Formula C27H42CINO2
Description

a potent medium-lasting selective M2 muscarinic receptor antagonist.

Cervane alkaloid C27H42CINO2 derivative of Imperialine from the plant Petilium eduardi.
 
Biological Activity

3-β-Chloro-Imperialine‚ medium-lasting cholinoblocker of M2 receptors‚ blocks M2 receptors in the heart at 10 µg/kg (i.v.).
3-β-Chloro-Imperialine activity is 10 times higher than that of Imperialine.
 
Chemical and Physical Properties
 
CAS No. 153720-49-1 Molecular Weight 447 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 4840 Melting point 203-208 °C.
PubChem SID Solubility chloroform; not well in acetone‚ methanol‚ ethanol‚ water.
Purity 97% (TLC). Optical Activity
Toxicity (LD50) mice (i.v.): 46 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Eglen et al., "Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro." Naunyn-Schmiedeberg’s Arch. Pharmacol. (1992) 346:144-151
  2. on 3-b-Bromo-Imperialine: Mirzaev, unbublished results.
 
Prices
Code
Quantity
US $
€uro
L6033
1 x 1 mg
168.00
120.00
5 x 1 mg
672.00
480.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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