aBungarotoxin neuronal nicotinic receptor antagonist with a selectivity comparable to that of Methyllycaconitine at the brain sites (nanomolar affinity); potent medium-acting non depolarizing neuromuscular blocker; muscle relaxant.

Alkaloid C₃₈H₅₀N₂O₁₁.HClO₄ from plants of the Ranunculaceae family.

• Molecular Weight : 810.5 Da.
  
  
• Melting Point : 209-212 °C.
  
  
• Solubility in : ethanol.
  
  
• Purity min. : 96% (TLC, mass-spectrometry).
  
  
• Biological Activity : recent studies (see attached sheet) show that Nudikauline perchlorate acts as neuronal a-Bungarotoxin-sensitive brain nicotinic receptors antagonist, with a comparable affinity to Methyllycaconitine.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 1.8 mg/kg. mice (i.p.): 13.0 mg/kg. mice (orally): 38.0 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 99815-83-5
  
  
• Bibliography :
  
  1. Kulanthaivel et al., Heterocycles (1985). 23:2515