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Home Page > Alphabetical Index > TETRAHYDROPALMATINE HCl ((dl)-)
| TETRAHYDROPALMATINE HCl ((dl)-) Prod. No L6038 - CAS # 6024-85-7 |
| Product Name | TETRAHYDROPALMATINE HCl ((dl)-) |
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| Product Code | L6038 | ![]() C21H25NO4.HCl |
| Molecular Formula | C21H25NO4.HCl | |
| Description | a D1/D2 Dopaminergic receptors antagonist presenting analgesic and sedative/tranquillizing effects; voltage dependent Ca2+ channel blocker; antiarrhythmic and hypotensive. Stephania glabra diisoquinoline alkaloid C21H25NO4.HCl synthetic |
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| Biological Activity | Tetrahydropalmatine presents a sedative/tranquillizing effect probably due to its antagonistic action on D1/D2 receptors in brain (Vauquelin et al. 1989). The effect of Tetrahydropalmatine on the left auricle of the guinea pig is similar to that of verapamil and antagonistic to calcium. Tetrahydropalmatine mainly inhibits voltage-dependent Ca2+ channels [5]; 6-12 mg/kg (i.v.) 30 mg/kg (i.p.) and 60 mg/kg (s.c.) suppress arrhythmia caused by Strophanthin Aconitine and CaCl2 (Yu-Wan et al. 1987). |
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| Chemical and Physical Properties | |||||||||||||||
| CAS No. | 6024-85-7 | Molecular Weight | 391.7 Da. | ||||||||||||
| RTECS | Physical Form | ||||||||||||||
| Merck Index No (13th Ed.) | 6945 | Melting point | 250-252 °C. | ||||||||||||
| PubChem SID | Solubility | water. | |||||||||||||
| Purity | 95% (TLC mass-spectrometry). | Optical Activity | |||||||||||||
| Toxicity (LD50) | mice (orally): 1 160 mg/kg. rats (orally): 930 mg/kg. mice (s.c.): 670 mg/kg. |
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| Storage & Reconstitution Recommendations | Store at +4°C in dark place. | ||||||||||||||
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