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Home Page > Alphabetical Index > TETRAHYDROPALMATINE HCl ((d‚l)-)

TETRAHYDROPALMATINE HCl ((d‚l)-) Prod. No L6038 - CAS # 6024-85-7
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Product Name TETRAHYDROPALMATINE HCl ((d‚l)-)
Product Code L6038
TETRAHYDROPALMATINE HCl ((d‚l)-)

C21H25NO4.HCl
Molecular Formula C21H25NO4.HCl
Description

a D1/D2 Dopaminergic receptors antagonist presenting analgesic and sedative/tranquillizing effects; voltage dependent Ca2+ channel blocker; antiarrhythmic and hypotensive.

Stephania glabra diisoquinoline alkaloid C21H25NO4.HCl ‚ synthetic
 
Biological Activity

Tetrahydropalmatine presents a sedative/tranquillizing effect‚ probably due to its antagonistic action on D1/D2 receptors in brain (Vauquelin et al.‚ 1989). The effect of Tetrahydropalmatine on the left auricle of the guinea pig is similar to that of verapamil and antagonistic to calcium. Tetrahydropalmatine mainly inhibits voltage-dependent Ca2+ channels [5]; 6-12 mg/kg (i.v.)‚ 30 mg/kg (i.p.) and 60 mg/kg (s.c.) suppress arrhythmia caused by Strophanthin‚ Aconitine and CaCl2 (Yu-Wan et al.‚ 1987).
 
Chemical and Physical Properties
 
CAS No. 6024-85-7 Molecular Weight 391.7 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 6945 Melting point 250-252 °C.
PubChem SID Solubility water.
Purity 95% (TLC‚ mass-spectrometry). Optical Activity
Toxicity (LD50) mice (orally): 1 160 mg/kg.
rats (orally): 930 mg/kg.
mice (s.c.): 670 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Vauquelin et al., "(+-) tetrahydroanisocycline and (+-) tetrahydropalmatine binding to D1 and D2 Dopaminergic receptors in human putamen". Neurochem. Int. (1989) 15(3):321-324
  2. Marcenac et al. "Effect of l-tetrahydropalmatine on dopamine release and metabolism in the rat striatum." Psychopharmacology (1989). 89:89-93
  3. Chen et al. "Calcium antagonists from traditional Chinese herbs." Drug News and Perspectives (1990). 3(7):425-428
  4. Zhao et al. "Effects of dl-Tetrahydropalmatine on contractions of rabbit aortic strips." Acta Pharmacologica Sinica (Chinese; abstract in English) (1988). 9(2):153-155
 
Prices
Code
Quantity
US $
€uro
L6038
5 mg
106.40
76.00
25 mg
425.60
304.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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