a psychotomimetic agent on dogs and cats; acetylcholinesterase inhibitor.

Alkaloid C₁₁H₁₂N₂O derivative of Desoxypeganine from plants of the Zygophyllaceae family.

• Molecular Weight : 188 Da.
  
  
• Melting Point : 176-178 °C. (decomp.)
  
  
• Solubility in : moderately soluble in chloroform, ethanol.
  
  
• Purity min. : 95 %.
  
  
• Biological Activity : * psychotomimetic effects: (unpublished results) dogs are specially sensitive to the psychotomimetic effects of Peganole. - 0.5 mg/kg (s.c.) on dogs (5-10 mg/kg on rats): disruption of conditioned reflex. - 1.0 mg/kg (i.v.): burst of motor activity and aggressiveness; usually gentle dogs start growling, barking and biting various objects with fury during 15 to 20 minutes. After this period, dogs are depressed during 4 to 6 hours. - 3-5 mg/kg (i.v.) inhibit the synchronization of the main rhythm in the cortex and the reticular formation (activation reaction). - 31 mg/kg and 62 mg/kg (respectively 0.25 and half DL50) enhance respectively 2 and 2.5 times the length of sleep caused by chloral hydrate, although Peganole does not possess any soporific effect by itself. * cholinergic effects: the main cholinergic effects of Peganole on mice (i.p., i.v. and s.c.) are as follow: - speeds up the breath rhythm; - causes tremor and clonic cramps; - enhances salivation and blood pressure; Peganole increases the effects of the cholinergic transmission in the CNS and at the neuromuscular junction; at 15, 30 and 50 mg/kg (i.p.), increases respectively 1.5, 2 and 2.5 times the effects of Arecoline on tremor and 1.0, 1.8 and 3 times the effects of Nicotine. Inhibits both cholinesterases and monoamine oxydases.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 62 mg/kg. mice (i.p.): 130 mg/kg. mice (s.c.): 237 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 36101-54-9
  
  
• Bibliography :
  
  1. Telejnetskaya et al., Chem. Nat. Comp. (1971). 6:849
  2. Telejnetskaya et al., Chem. Nat. Comp. (1989). 6:857