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Home Page > Alphabetical Index > TRICHODESMINE

TRICHODESMINE Prod. No L6049 - CAS # 548-90-3
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Product Name TRICHODESMINE
Product Code L6049
TRICHODESMINE

C18H27O6N
Molecular Formula C18H27O6N
Description

causes encephalopathy ; probably also hepatotoxic.

Pyrrolizidine alkaloid C18H27O6N ‚ from the plant Trichodesma incanum‚ Boraginaceae.
 
Biological Activity

Poisoning by Trichodesma incanum‚ which contains mainly Trichodesmine and Incanine‚ presents the following clinical symptoms after a latent period of about 10 days [3]:
- vertigo;
- recurring headaches leading to nausea and vomiting;
- generalized malaise;
- delirium‚ loss of consciousness;
- death by respiratory depression.
 
Chemical and Physical Properties
 
CAS No. 548-90-3 Molecular Weight 353 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 160 °C.
PubChem SID Solubility well in methanol‚ ethanol‚ chloroform‚ acetone and water.
Purity Optical Activity [a]D + 38° (c = 10% in ethanol).
Toxicity (LD50) 10-15 mg/kg (s.c.) of Trichodesma alkaloids produce death in mice rabbits or dogs within 2 to 6 hours as a result of respiratory depression. Higher doses produce immediate death.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Huxtable, "Human health implications of pyrrolizidine alkaloids and herbs containing them." Toxicants of Plant Origin, vol. 1., Peter R. Cheeke Ed., (CRC Press Inc., Boca Raton, Florida, 1989), p.41-86
  2. Zalkow et al., "Pyrrolizidine alkaloids from middle eastern plants." Journal of Natural Products (1979). 42:603-614
  3. Ismailov et al., "Klinika, diagnostica i lecheniye, trichodesmotokikoza [Clinical signs, diagnosis and treatments of Trichodesma toxicosis (alimentary toxic encephalopathy)]." Meditsina (Taschkent, UzSSR) (1970) (Russian). 85
 
Prices
Code
Quantity
US $
€uro
L6049
5 mg
106.40
76.00
25 mg
425.60
304.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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