TRICHODESMINE - LATOXAN Technical Data Sheet
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L6049 TRICHODESMINE

causes encephalopathy ; probably also hepatotoxic.

Pyrrolizidine alkaloid C18H27O6N from the plant Trichodesma incanum, Boraginaceae.


PRICES
QuantityUS DollarsEURO
5 mg 106.40 76.00
25 mg 425.60 304.00


  • Molecular Weight : 353 Da.

  • Melting Point : 160 °C.

  • Solubility in : well in methanol, ethanol, chloroform, acetone and water.

  • Biological Activity : Poisoning by Trichodesma incanum, which contains mainly Trichodesmine and Incanine, presents the following clinical symptoms after a latent period of about 10 days [3]: - vertigo; - recurring headaches leading to nausea and vomiting; - generalized malaise; - delirium, loss of consciousness; - death by respiratory depression.

  • Toxicity (LD50) : 10-15 mg/kg (s.c.) of Trichodesma alkaloids produce death in mice rabbits or dogs within 2 to 6 hours as a result of respiratory depression. Higher doses produce immediate death.

  • Storage recommendations : Store at +4°C, in dark place.

  • CAS Reg. No. : 548-90-3

  • Bibliography :
    1. Huxtable, "Human health implications of pyrrolizidine alkaloids and herbs containing them." Toxicants of Plant Origin, vol. 1., Peter R. Cheeke Ed., (CRC Press Inc., Boca Raton, Florida, 1989), p.41-86
    2. Zalkow et al., "Pyrrolizidine alkaloids from middle eastern plants." Journal of Natural Products (1979). 42:603-614
    3. Ismailov et al., "Klinika, diagnostica i lecheniye, trichodesmotokikoza [Clinical signs, diagnosis and treatments of Trichodesma toxicosis (alimentary toxic encephalopathy)]." Meditsina (Taschkent, UzSSR) (1970) (Russian). 85



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    Revised : 26/04/2007 10:28 - Copyright © Latoxan