- Molecular Weight : 427 Da.
- Melting Point : 228-235 °C.
- Solubility in : dissolves well in chloroform, slightly in methanol and ethanol, not well in acetone.
- Purity min. : 97% (TLC).
- Biological Activity : presents a M2-selective activity: ED50 on rats under anaesthesia (i.v.) is 0.019 mg/kg (77.5% of Atropine activity).
On the other muscarinic receptor subtypes, the effects of Imperialone are the following:
- M4 receptors from rat intestine, EC50 = 7.4 10-8 g/ml (4.8% of Atropine activity).
- M3 receptors from rat salivary glands, ED50 = 16.2 mg/kg (0.027 % of Atropine activity).
Imperialone is more potent and presents a 3 to 5 times longer M2 cholinoblocking effect than L60 08 Imperialine at similar concentration. Therefore, it can be considered as a medium-acting cholinoblocker.
- Toxicity (LD50) : mice (i.v.): 44 mg/kg. (36-52)
- Storage recommendations : Store at +4°C, in dark place.
- CAS Reg. No. : 61989-75-1
- Bibliography :
- Nurridinov et al., Chem. Nat. Comp. (1968). 333
- Mirzaev, unbublished results.
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