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Home Page > Alphabetical Index > IMPERIALONE

IMPERIALONE Prod. No L6050 - CAS # 61989-75-1
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Product Name IMPERIALONE
Product Code L6050
IMPERIALONE

C27H41NO3
Molecular Formula C27H41NO3
Description

a medium-lasting and selective M2 muscarinic receptors antagonist (potency is intermediate between that of L60 08 Imperialine and L60 32/L60 33 chloro-Imperialines).

Alkaloid C27H41NO3 derivative of Imperialine extracted from Petilium eduardi.
 
Biological Activity

presents a M2-selective activity: ED50 on rats under anaesthesia (i.v.) is 0.019 mg/kg (77.5% of Atropine activity).
On the other muscarinic receptor subtypes‚ the effects of Imperialone are the following:
- M4 receptors from rat intestine‚ EC50 = 7.4 10-8 g/ml (4.8% of Atropine activity).
- M3 receptors from rat salivary glands‚ ED50 = 16.2 mg/kg (0.027 % of Atropine activity).
Imperialone is more potent and presents a 3 to 5 times longer M2 cholinoblocking effect than L60 08 Imperialine at similar concentration. Therefore‚ it can be considered as a medium-acting cholinoblocker.
 
Chemical and Physical Properties
 
CAS No. 61989-75-1 Molecular Weight 427 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 228-235 °C.
PubChem SID Solubility dissolves well in chloroform‚ slightly in methanol and ethanol‚ not well in acetone.
Purity 97% (TLC). Optical Activity [a]D -31.7°.
Toxicity (LD50) mice (i.v.): 44 mg/kg. (36-52)
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Nurridinov et al., Chem. Nat. Comp. (1968). 333
  2. Mirzaev, unbublished results.
 
Prices
Code
Quantity
US $
€uro
L6050
1 x 1 mg
159.60
114.00
5 x 1 mg
638.40
456.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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