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Home Page > Alphabetical Index > COLCHICINE

COLCHICINE Prod. No L6051 - CAS # 64-86-8
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Product Name COLCHICINE
Product Code L6051
COLCHICINE

C22H25NO6
Molecular Formula C22H25NO6
Description

tubulin polymerisation inhibitor: potent antimitotic; anti-inflammatory; antifibrogenic.

Alkaloid‚ C22H25NO6 ‚ from the plant Colchicum speciosum‚ Liliaceae.
 
Biological Activity

antimitotic: binds to one tubulin end and prevents its polymerisation; causes disappearence of the mitotic spindle and blocks the cell in mitosis.
anti-inflammatory: inhibits IL-1 production by peripheral blood monocytes‚ the release of growth factors by Kupffer cells and macrophages‚ the chemotactic migration of inflammatory cells into the liver [1].
antifibrogenic: inhibits microtubule assembly and thus prevent the transport and secretion of collagene; induces collagenase activity [1].
acts on liver functions: modifies membrane fluidity‚ increases membrane enzymes acivities and glycogen levels [1].
 
Chemical and Physical Properties
 
CAS No. 64-86-8 Molecular Weight 399.44 Da.
RTECS Physical Form white to yellowish crystal powder
Merck Index No (13th Ed.) 2470 Melting point 153-155 °C.
PubChem SID Solubility alcohols‚ acetone and chloroform; slightly in water; not in ether.
Purity 97 % (melting point‚ NMR‚ TLC). Optical Activity [a]D - 120° (c = 1.0 in chloroform).
Toxicity (LD50) LD50 rat (i.v.; s.c.; i.m.): 2.0 ± 0.3 mg/kg
LD100 mice (i.v.; s.c.; i.m.): 5 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations store at +4°C‚ in a dark place.
Safety Recommendations
 
Bibliographic References
  1. Rojkind, Pharmacology & Therapeutics (1992). 53(1)
  2. Andreu J.M. et al., Proc. Nat. Acad. Sci. USA (1982). 79:6756
  3. Salmon E.D. et al., J. Cell. Biol. (1984). 99:106
 
Prices
Code
Quantity
US $
€uro
L6051
50 mg
98.00
70.00
250 mg
392.00
280.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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