Antiarrhythmic and hypotensive; ganglioblocker; presents weak affinity at brain aBungarotoxin-sensitive nAChR.

Alkaloid C₂₆H₄₁NO₇ from plants of the Ranunculaceae family.

• Molecular Weight : 479 Da.
  
  
• Melting Point : 202-203 °C.
  
  
• Solubility in : chloroform; not well in ethanol and methanol.
  
  
• Purity min. : 97% (TLC, mass spectrometry).
  
  
• Biological Activity : antiarrhythmic effects of Delcorine: ED50 on various models of experimental arrhythmias (i.v.) ranges from 10 to 20 mg/kg. At these concentrations, the product blocks during a short period the neuronal conductivity in sympathetic ganglia and causes hypotension.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 116 mg/kg.
  mice (i.p.): 590 mg/kg
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 52358-55-1
  
  
• Bibliography :
  
  1. Narzullaev et al., Chem. Nat. Comp. (1973). 4:497
  2. Salimov et al., Chem. Nat. Comp. (1985). 1:95