a potent antiarrhytmic and local anesthetic.

Alkaloid C₂₀H₂₇NO₃.HCl from plants of the Ranunculaceae family.

• Molecular Weight : 365 Da.
  
  
• Melting Point : 290 °C. (decomp.)
  
  
• Solubility in : water; not well in ethanol and methanol.
  
  
• Purity min. : 97 % (TLC, mass spectrometry).
  
  
• Biological Activity : the dosage for antiarrhythmic activity in mammals ranges from 0.1 to 1.0 mg/kg and is the most effective in arrythmias caused by calcium chloride (200-250 mg/kg). ED50 for antifibrillatory activity in rat is 0.15 mg/kg.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 26.2 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 149926-20-5
  
  
• Bibliography :
  
  1. Pelletier et al., Phytochemistry (1968). 7:625-635