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Home Page > Alphabetical Index > AUSTRICINE

AUSTRICINE Prod. No L6055 - CAS # 10180-88-8
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Product Name AUSTRICINE
Product Code L6055
AUSTRICINE

C15H18O4.H2O
Molecular Formula C15H18O4.H2O
Description

a hypolipidemic‚ antiatherosclerotic‚ anti-inflammatory agent‚ with angioprotective and hepatoprotective activity; antiulcerous.

Sesquiterpene lactone C15H18O4.H2O ‚ from plants of the Compositae family.
 
Biological Activity

at 1 mg/kg during 90 days‚ given with cholesterol‚ the preparation decreases the area of atherosclerotic damage in aorta‚ the cholesterol content in this area‚ the thickness and size of the atherosclerotic plaque.
The preparation decreases the aorta and microvessels permeability for high molecular albumine-blue Evans complex‚ which is increased by feeding with cholesterol or administration of bradykine or ovalbumine.
All major lipid classes content in blood serum and liver is decreased after administration of Austricine.
 
Chemical and Physical Properties
 
CAS No. 10180-88-8 Molecular Weight 262 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point melts slightly at 123-125 °C.‚ then hardens and melts at 149-151 °C. (alcohol).
PubChem SID 447061 Solubility acetone‚ ethylacetate‚ dimethylformamide‚ DMSO; not in water.
Purity 98 % (TLC‚ mass spectrometry). Optical Activity [a]25 + 28 (c 1.1 chloroform).
D
Toxicity (LD50) mice (orally): 5 g/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Rybalko, J. Gen. Chem. (1963) (Russian). 33(8):2734
  2. Syrov et al., Chem. Pharm. J. (1991) (Russian). 2:42-45
 
Prices
Code
Quantity
US $
€uro
L6055
100 mg
142.80
102.00
500 mg
571.20
408.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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