a short-acting muscle relaxant, twice as active as d-tubocurarine; possessing M₂- and N- cholinolytic properties; also presenting antihistaminic activity.

Tropane alkaloid C₃₈H₅₂N₂O₄Cl₂ derivative of b-Belladonnine from the plant Atropa belladonna, Solanaceae.

• Molecular Weight : 670 Da.
  
  
• Melting Point : 242-243 °C.
  
  
• Solubility in : ethanol, methanol and water; not well in acetone and chloroform.
  
  
• Purity min. : 97 % (TLC).
  
  
• Biological Activity : b-Belladonnine selectively blocks heart M-receptors (ED50: 13 µg/kg): a blockage of smooth muscles and secretory organs M-cholinoreceptors requires a 10 to 20 times higher concentration. b-Belladonnine also blocks skeletal muscles N-cholinoreceptors (ED50: 50-60 mg/kg).
  
  
• Toxicity (LD₅₀) : mice (i.v.): 0.223 mg/kg. mice (s.c.): 0.394 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 191355-47-2
  
  
• Merck Index 11th Ed. : 1035