a substance presenting an estrogenic activity and sedative effects.

Lignan C₂₂H₂₆O₆ from plants of the Rutaceae family.

• Molecular Weight : 386 Da.
  
  
• Melting Point : 107-108 °C.
  
  
• Solubility in : chloroform; very slightly in alcohol and acetone; not in water.
  
  
• Purity min. : 97 % (TLC).
  
  
• Biological Activity : Eudesmine presents a short acting estrogenic activity and a sedative effect. - 1.5 and 10 mg/kg cause a mass increase of the uterus in non-pubescent rats and induces oestrus in ovarectomized pubescent rats. - 50 and 100 mg/kg cause a general relaxation of the animals and extends by 2.5 times the effects of soporifics. - 100, 200 and 500 mg/kg present no effect on the convulsant activity of Caffeine (300 mg/kg), Corazole (Pentylenetrazole) (75 mg/kg) and Strychnine (1 mg/kg).
  
  
• Toxicity (LD₅₀) : mice (orally): 1 900 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 526-06-7
  
  
• Bibliography :
  
  1. Whiting. Natural Products Reports (1985). 2:195
  2. Atal et al., Am. Journ. Chem. Soc. (1967). (c) 2228