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Home Page > Alphabetical Index > HETERATISINE

HETERATISINE Prod. No L6061 - CAS # 3328-84-5
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Product Name HETERATISINE
Product Code L6061
HETERATISINE

C22H33NO5
Molecular Formula C22H33NO5
Description

a potent antiarrhythmic‚ antifibrillatory; Na+ channel blocker in cardiomyocytes.

C19-norditerpenoid alkaloid C22H33NO5 ‚ from plants of the Ranunculaceae family.
 
Biological Activity

antiarrhythmic and antifibrillatory activity on experimental arrhythmias caused by Aconitine‚ calcium chloride‚ cardiac electric stimulation and artery occlusion; the active dosage ranges from 5 to 20 mg/kg in mammals. Heteratisine is more active‚ more cardioselective and less toxic than Quinidine.
 
Chemical and Physical Properties
 
CAS No. 3328-84-5 Molecular Weight 391 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 259-260 °C.
PubChem SID Solubility chloroform and methanol; not well in acetone and ethanol.
Purity 97 % (TLC‚ mass spectrometry). Optical Activity
Toxicity (LD50) mice (i.v.): 180 mg/kg.
mice (i.p.): 430 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
20 mg of Heteratisine dissolve in 0.3 ml 3 % HCl.
Safety Recommendations
 
Bibliographic References
  1. Pelletier et al., Phytochemistry (1968). 7:625
  2. Aneja et al., Tetrahedron (1973). 29:3297
 
Prices
Code
Quantity
US $
€uro
L6061
10 mg
134.40
96.00
50 mg
537.60
384.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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