HETERATISINE - LATOXAN Technical Data Sheet
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L6061 HETERATISINE

a potent antiarrhythmic, antifibrillatory; Na+ channel blocker in cardiomyocytes.

C19-norditerpenoid alkaloid C22H33NO5 from plants of the Ranunculaceae family.


PRICES
QuantityUS DollarsEURO
10 mg 134.40 96.00
50 mg 537.60 384.00


  • Molecular Weight : 391 Da.

  • Melting Point : 259-260 °C.

  • Solubility in : chloroform and methanol; not well in acetone and ethanol.

  • Purity min. : 97 % (TLC, mass spectrometry).

  • Biological Activity : antiarrhythmic and antifibrillatory activity on experimental arrhythmias caused by Aconitine, calcium chloride, cardiac electric stimulation and artery occlusion; the active dosage ranges from 5 to 20 mg/kg in mammals. Heteratisine is more active, more cardioselective and less toxic than Quinidine.

  • Toxicity (LD50) : mice (i.v.): 180 mg/kg. mice (i.p.): 430 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place. 20 mg of Heteratisine dissolve in 0.3 ml 3 % HCl.

  • CAS Reg. No. : 3328-84-5

  • Bibliography :
    1. Pelletier et al., Phytochemistry (1968). 7:625
    2. Aneja et al., Tetrahedron (1973). 29:3297



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan