a potent antiarrhythmic, antifibrillatory; Na⁺ channel blocker in cardiomyocytes.

C₁₉-norditerpenoid alkaloid C₂₂H₃₃NO₅ from plants of the Ranunculaceae family.

• Molecular Weight : 391 Da.
  
  
• Melting Point : 259-260 °C.
  
  
• Solubility in : chloroform and methanol; not well in acetone and ethanol.
  
  
• Purity min. : 97 % (TLC, mass spectrometry).
  
  
• Biological Activity : antiarrhythmic and antifibrillatory activity on experimental arrhythmias caused by Aconitine, calcium chloride, cardiac electric stimulation and artery occlusion; the active dosage ranges from 5 to 20 mg/kg in mammals. Heteratisine is more active, more cardioselective and less toxic than Quinidine.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 180 mg/kg. mice (i.p.): 430 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place. 20 mg of Heteratisine dissolve in 0.3 ml 3 % HCl.
  
  
• CAS Reg. No. : 3328-84-5
  
  
• Bibliography :
  
  1. Pelletier et al., Phytochemistry (1968). 7:625
  2. Aneja et al., Tetrahedron (1973). 29:3297