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Home Page > Alphabetical Index > LEUCOMISINE

LEUCOMISINE Prod. No L6067 - CAS # 17946-87-1
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Product Name LEUCOMISINE
Product Code L6067
LEUCOMISINE

C15H18O3
Molecular Formula C15H18O3
Description

an antiatherosclerotic‚ angioprotective‚ hypolipidemic and anti-inflammatory.

Sesquiterpene lactone C15H18O3 ‚ from plants of the Compositae family.
 
Biological Activity

1 mg/kg during 90 days‚ decrease the size and thickness of atherosclerotic discs‚ the amount of foam cells and the cholesterol content in aorta of rabbits fed with high cholesterol level diet.
It also reduces the permeability increase of aorta and microvessels for high molecular weight albumin-Blue Evans complex caused by Cholesterol‚ Bradykinin‚ Ovalbumin or Histamine.
In blood serum and in liver‚ Leucomisine also presents an hypolipidemic activity on all major lipid classes‚ especially esters of cholesterols.
 
Chemical and Physical Properties
 
CAS No. 17946-87-1 Molecular Weight 246 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 199-200 °C.
PubChem SID Solubility chloroform‚ acetone‚ ethylacetate‚ benzole; not in water.
Purity 98 % (TLC‚ mass spectrometry). Optical Activity 20
[a]D + 56° (c = 1.5 in chloroform).
Toxicity (LD50) mice (orally): 5 000 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Rybalko. J. obsh. Khimiya (1963)(Russian) 33(8):2734
  2. Kurmukov et al., Pharmacol. Toxicol. (1991) (Russian). 54(3):35-37
 
Prices
Code
Quantity
US $
€uro
L6067
100 mg
152.60
109.00
500 mg
610.40
436.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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