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Home Page > Alphabetical Index > NITRARINE DIHYDROCHLORIDE

NITRARINE DIHYDROCHLORIDE Prod. No L6068 - CAS # 20069-05-0
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Product Name NITRARINE DIHYDROCHLORIDE
Product Code L6068
NITRARINE DIHYDROCHLORIDE

C20H25N3.2HCl

Molecular Formula C20H25N3.2HCl
Description

a hypotensive‚ spasmolytic‚ coronary dilator‚ sedative in experimental arrhythmias.

Alkaloid C20H25N3.2HCl ‚ from plants of the Zygophyllaceae family.

 
Biological Activity

in experimental arrhythmias in the cat‚ caused by calcium chloride‚ Aconitine and electric cardiac stimulation‚ Nitrarine dihydrochloride presents a hypotensive‚ spasmolytic‚ coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine‚ and the duration of its effect is 2-5 times longer than that of these products.

 
Chemical and Physical Properties
 
CAS No. 20069-05-0 Molecular Weight 380 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 265-266 °C.
PubChem SID Solubility well in water‚ methanol and ethanol.
Purity 97 %. Optical Activity
Toxicity (LD50) mice (i.v.): 117 mg/kg (1 % solution).
mice (underdermally): 520 mg/kg (2 % solution).
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Nasirov et al. Chem. Nat. Comp. (1976). 3:334-345
  2. Aminov et al. Chem. Pharm. J. (1991) (Russian). 3:56-58
 
Prices
Code
Quantity
US $
€uro
L6068
50 mg
100.80
72.00
250 mg
403.20
288.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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