a hypotensive, spasmolytic, coronary dilator, sedative in experimental arrhythmias.

Alkaloid C₂₀H₂₅N₃.2HCl from plants of the Zygophyllaceae family.

• Molecular Weight : 380 Da.
  
  
• Melting Point : 265-266 °C.
  
  
• Solubility in : well in water, methanol and ethanol.
  
  
• Purity min. : 97 %.
  
  
• Biological Activity : in experimental arrhythmias in the cat, caused by calcium chloride, Aconitine and electric cardiac stimulation, Nitrarine dihydrochloride presents a hypotensive, spasmolytic, coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine, and the duration of its effect is 2-5 times longer than that of these products.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 117 mg/kg (1 % solution). mice (underdermally): 520 mg/kg (2 % solution).
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 20069-05-0
  
  
• Bibliography :
  
  1. Nasirov et al. Chem. Nat. Comp. (1976). 3:334-345
  2. Aminov et al. Chem. Pharm. J. (1991) (Russian). 3:56-58