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Home Page > Alphabetical Index > VERATROYLZYGADENINE

VERATROYLZYGADENINE Prod. No L6077 - CAS # 31329-58-5
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Product Name VERATROYLZYGADENINE
Product Code L6077
VERATROYLZYGADENINE

C36H51NO10
Molecular Formula C36H51NO10
Description

an analog of Veratridine; Na+ channel activator; potent neurotoxic; depolarizing agent on membranes of nerve terminal‚ muscle and gland cells.

Steroid alkaloid C36H51NO10 ‚ from plants of the Veratrum genus‚ Liliaceae.
 
Biological Activity

analog of Veratridine; effect on cardiac vessel system at the dosage of 1-50 µg/kg intravenously.
 
Chemical and Physical Properties
 
CAS No. 31329-58-5 Molecular Weight 657 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 259-261 °C.
PubChem SID Solubility chloroform + methanol pyridine; not well in ethanol‚ chloroform‚ water‚ acetone.
Purity 96 % (TLC‚ mass spectrometry). Optical Activity
Toxicity (LD50) mice (i.v.): 0.77 mg/kg (0.66-0.89).
mice (s.c): 9.2 mg/kg (8.1-10.5).
Chemical Names
Storage & Reconstitution Recommendations Stable in freeze-dried state; store at +4°C‚ in dark place. Stable several months in solution.
Safety Recommendations
 
Bibliographic References
  1. Kupchan. "Veratrum alkaloids. XXX. The structure and configuration of zygadenine." J. Amer. Chem. Soc. (1959). 81:1925
  2. Fink et al., "Veratridine and other depolarizing agents counteract the inhibitory effect of Mg++ ion..."Nannyn-Schmiedeberg’s Arch. Pharmacol. (1990). 342N(1):53-60
  3. Tarvin et al., "Glucose induced electrical activity in the pancreatic beta-cells: effect of veratridine." Amer. J. Physiol. (1981). 240:127-134
  4. Honerjager, "A neutrally mediated inotropic effect of veratridine and sevadine on isolated guinea pig papillary muscle." Nannyn Schmiederberg's Arch. Pharmacol. (1980). 314:157-160
 
Prices
Code
Quantity
US $
€uro
L6077
10 mg
51.80
37.00
50 mg
207.20
148.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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