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Home Page > Alphabetical Index > BENZOYLHETERATISINE HCl

BENZOYLHETERATISINE HCl Prod. No L6085 - CAS #
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Product Name BENZOYLHETERATISINE HCl
Product Code L6085
BENZOYLHETERATISINE HCl

C29H37NO6.HCl
Molecular Formula C29H37NO6.HCl
Description

a Na+ channel blocker; potent antiarrhythmic; local anesthetic.

C19-diterpenoid alkaloid C29H37NO6.HCl ‚ from plants of the Ranunculaceae family.
 
Biological Activity

Strongly antagonizes the effects of Aconitine; the basic mechanism of action is the inhibition of Na+ conductivity of excitable cells. The Na+ channel blockage level does not depend on the potential and stimulus intensity. Its antiarrhythmic activity level is higher than that of Quinidine‚ and its mechanism of action significantly differs from that of other class I antiarrhythmics.
 
Chemical and Physical Properties
 
CAS No. Molecular Weight 531 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 209-211 °C. (decomp. alcohol)
PubChem SID Solubility water; moderately in methanol; not well in ethanol.
Purity 97 % (TLC‚ mass spectrometry‚ NMR). Optical Activity
Toxicity (LD50) rats (i.v.): 5.0 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations - for experiments on antiarrhythmic effects: 0.05 mg/kg to 0.5 mg/kg;
- for anesthetic activity on nerve terminals: 0.1% to 0.5% solution;
- for in vitro experiments: 10-9-10-8 M solution.
Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Aneja et al., "The diterpene alkaloids: the structure and stereochemistry of heteratisine." Tetrahedron (1973). 29 (21):3297-3308
 
Prices
Code
Quantity
US $
€uro
L6085
5 mg
74.20
53.00
25 mg
296.80
212.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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