an anesthetic acting on the nerve endings, with a good selectivity on sensory nerves; lowers arterial pressure; vasodilator.

Tropane alkaloid C₁₆H₂₁NO₄ from plants of the Convolvulaceae family.

• Molecular Weight : 291 Da.
  
  
• Melting Point : 114-115 °C.
  
  
• Solubility in : acetone, ethanol, methanol.
  
  
• Purity min. : 97 % (TLC, mass spectrometry)
  
  
• Biological Activity : A 0.125 % solution blocks the sensitive nerve endings in frog skin and extends the latency of the reflex response to a painful stimulus. The effect, developing gradually, reaches a maximum 55-60 minutes after application and lasts up to 2 hours. Convolvine (1/1000 to 1/3000) inhibits cardiac activity, dilates the vessels from isolated ear of rabbit; at 3 mg/kg, lowers the arterial pressure in decerebrated cats.
  
  
• Toxicity (LD₅₀) : mice (s.c.): 15-20 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place. Solution for use : 0.1 - 1 %.
  
  
• CAS Reg. No. : 537-30-4
  
  
• Bibliography :
  
  1. Oreckov et al. Khim. Pharm. Industr. (1933) (Russian). 1:52
  2. Oreckov et al. Journ. Org. Chem. (1937) (Russian). 7:646