GRAMINE - LATOXAN Technical Data Sheet
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L6088 GRAMINE
( Donaxine )

an inhibitor of acetylcholinesterase and butyrilcholinesterase.

Indole alkaloid C11H14N2 from the plant Arundo donax, Gramineae.


PRICES
QuantityUS DollarsEURO
100 mg 39.20 28.00
500 mg 156.80 112.00


  • Molecular Weight : 174 Da.

  • Melting Point : 138-139 °C.

  • Solubility in : chloroform, ethanol.

  • Purity min. : 97 % (TLC, mass spectrometry).

  • Biological Activity : 1-10 mg/kg on narcotized cats lower for a short period the arterial pressure; 10-5 and 10-4 g/ml cause inhibition of the intestine tonus and of pendulum contractions of isolated part of the intestine; does not present any myotic activity; highly enhances the action of acetylcholine on the leech dorsal muscle and the frog ventral muscle; in vitro, inhibits acetylcholinesterase and butyrilcholinesterase; at 1/5,700 concentration, lowers the brain and blood serum cholinesterase activity by 61%.

  • Toxicity (LD50) : mice (i.v.): 73.5 mg/kg. mice (s.c.): 215 mg/kg. rats (i.p.): 155 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place.

  • CAS Reg. No. : 87-52-5

  • Merck Index 11th Ed. : 4440

  • Bibliography :
    1. Oreckov et al. Journal Organitcheskoy Khimii. (1937) (Russian). 7:63
    2. Oubaydoullayef et al. Chem. Nat. Comp. (1976). 553
    3. Sadritinov et al., "Pharmacology of vegetal alkaloids and their use in medecin." Meditsina (Tashkent), (1980) (Russian).



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan