an inhibitor of acetylcholinesterase and butyrilcholinesterase.

Indole alkaloid C₁₁H₁₄N₂ from the plant Arundo donax, Gramineae.

• Molecular Weight : 174 Da.
  
  
• Melting Point : 138-139 °C.
  
  
• Solubility in : chloroform, ethanol.
  
  
• Purity min. : 97 % (TLC, mass spectrometry).
  
  
• Biological Activity : 1-10 mg/kg on narcotized cats lower for a short period the arterial pressure; 10-5 and 10-4 g/ml cause inhibition of the intestine tonus and of pendulum contractions of isolated part of the intestine; does not present any myotic activity; highly enhances the action of acetylcholine on the leech dorsal muscle and the frog ventral muscle; in vitro, inhibits acetylcholinesterase and butyrilcholinesterase; at 1/5,700 concentration, lowers the brain and blood serum cholinesterase activity by 61%.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 73.5 mg/kg. mice (s.c.): 215 mg/kg. rats (i.p.): 155 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place.
  
  
• CAS Reg. No. : 87-52-5
  
  
• Merck Index 11th Ed. : 4440
  
  
• Bibliography :
  
  1. Oreckov et al. Journal Organitcheskoy Khimii. (1937) (Russian). 7:63
  2. Oubaydoullayef et al. Chem. Nat. Comp. (1976). 553
  3. Sadritinov et al., "Pharmacology of vegetal alkaloids and their use in medecin." Meditsina (Tashkent), (1980) (Russian).