an inhibitor of acetylcholinesterase and butyrilcholinesterase.

Indole alkaloid C₁₁H₁₄N₂ ‚ from the plant Arundo donax‚ Gramineae.

1-10 mg/kg on narcotized cats lower for a short period the arterial pressure;
10-5 and 10-4 g/ml cause inhibition of the intestine tonus and of pendulum contractions of isolated part of the intestine;
does not present any myotic activity; highly enhances the action of acetylcholine on the leech dorsal muscle and the frog ventral muscle;
in vitro‚ inhibits acetylcholinesterase and butyrilcholinesterase; at 1/5‚700 concentration‚ lowers the brain and blood serum cholinesterase activity by 61%.

1. Oreckov et al. Journal Organitcheskoy Khimii. (1937) (Russian). 7:63
2. Oubaydoullayef et al. Chem. Nat. Comp. (1976). 553
3. Sadritinov et al., "Pharmacology of vegetal alkaloids and their use in medecin." Meditsina (Tashkent), (1980) (Russian).