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Home Page > Alphabetical Index > GLYROPHAMA DIHYDRATE

GLYROPHAMA DIHYDRATE Prod. No L6090 - CAS # 4207-90-3
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Product Name GLYROPHAMA DIHYDRATE
(Syn.: Amorphine)
Product Code L6090
GLYROPHAMA DIHYDRATE

C34H40O16.H2O
Molecular Formula C34H40O16.H2O
Description

an antiatherosclerotic and angioprotective; reduces platelet aggregation; reduces dysfunction of the hypophyseal/gonadic system.

Rotenoid glycoside C34H40O16.H2O ‚ from plants of the Leguminosae family.
 
Biological Activity

on experimental atherosclerosis in rabbit‚ Glyrophama dihydrate presents the following effects:
- reduces the area of the aorta damage by ~ 35 % or more;
- lowers (~ 2 times) the serumal global cholesterol‚ free cholesterol‚ cholesterol esters‚ and triglycerides level;
- enhances the HDL (a-cholesterol);
- prevents the aorta and vessels permeability due to hypocholesterolemia‚ acid acetic‚ formol‚ or external proteins;
- reduces the platelet aggregation‚ the hypercoagulation syndrom;
- reduces the hypophyseal/gonadic system dysfunction.
 
Chemical and Physical Properties
 
CAS No. 4207-90-3 Molecular Weight 722.7 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 158-161 °C.
PubChem SID 699344 Solubility pyridine‚ DMSO; not well in ethanol 95 % and acetone; not in chloroform and water.
Purity 97 % (TLC‚ mass spectrometry‚ NMR). Optical Activity
Toxicity (LD50) mice (orally): 255 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations stable in dry state; store at +4°C‚ in dark place. For in vitro experiments‚ the active concentration in DMSO is 10-6-10-9 M;
Safety Recommendations
 
Bibliographic References
  1. Acree et al., J. Org. Chem. (1973). 8:572
  2. Kurmukov et al., J. Mol. Cell. Cardiol. (1989). 21(suppl. 4):S15
  3. Aizikov et al., J. Mol. Cell. Cardiol. (1993). 25 (suppl.)
 
Prices
Code
Quantity
US $
€uro
L6090
50 mg
105.00
75.00
250 mg
420.00
300.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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