an antiatherosclerotic and angioprotective; reduces platelet aggregation; reduces dysfunction of the hypophyseal/gonadic system.

Rotenoid glycoside C₃₄H₄₀O₁₆.H₂O from plants of the Leguminosae family.

• Molecular Weight : 722.7 Da.
  
  
• Melting Point : 158-161 °C.
  
  
• Solubility in : pyridine, DMSO; not well in ethanol 95 % and acetone; not in chloroform and water.
  
  
• Purity min. : 97 % (TLC, mass spectrometry, NMR).
  
  
• Biological Activity : on experimental atherosclerosis in rabbit, Glyrophama dihydrate presents the following effects: - reduces the area of the aorta damage by ~ 35 % or more; - lowers (~ 2 times) the serumal global cholesterol, free cholesterol, cholesterol esters, and triglycerides level; - enhances the HDL (a-cholesterol); - prevents the aorta and vessels permeability due to hypocholesterolemia, acid acetic, formol, or external proteins; - reduces the platelet aggregation, the hypercoagulation syndrom; - reduces the hypophyseal/gonadic system dysfunction.
  
  
• Toxicity (LD₅₀) : mice (orally): 255 mg/kg.
  
  
• Storage recommendations : stable in dry state; store at +4°C, in dark place. For in vitro experiments, the active concentration in DMSO is 10-6-10-9 M;
  
  
• CAS Reg. No. : 4207-90-3
  
  
• Bibliography :
  
  1. Acree et al., J. Org. Chem. (1973). 8:572
  2. Kurmukov et al., J. Mol. Cell. Cardiol. (1989). 21(suppl. 4):S15
  3. Aizikov et al., J. Mol. Cell. Cardiol. (1993). 25 (suppl.)