non-selective antagonist at Muscarinic receptors.

Tropane alkaloid C₁₇H₂₃NO₃ from the plant Datura stramonium, Solanaceae.

• Molecular Weight : 289 Da.
  
  
• Melting Point : 109-110°C.
  
  
• Solubility in : well in acetone, DMSO, dimethylformamide and alcohol.
  
  
• Purity min. : 97 % (TLC, mass spectrometry).
  
  
• Biological Activity : as compared with the activity of Atropine, Hyoscyamine is 1.5-2 times as potent on the circular ocular muscle, 3 times as potent on the heart cholinoreceptors and 10 times as potent on the intestine cholinoreceptors.
  
  
• Toxicity (LD₅₀) : mice (i.p.): 190 mg/kg.
  
  
• Storage recommendations : store in darkness, at 4°C; solution for use: 0.1-1%.
  
  
• CAS Reg. No. : 101-31-5
  
  
• Merck Index 11th Ed. : 4795
  
  
• Bibliography :
  
  1. Nordgren et al., "Intoxication with anticholinesterases: effect of different combinations of antidotes on the dynamics of acetylcholine in mouse brain." Pharmacology & Toxicology (1992). 70(5):384-388