NOSCAPINE - LATOXAN Technical Data Sheet
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L6093 NOSCAPINE
( Narcotine )

an inhibitor of carbachol-stimulated phosphoinositide turnover; enhances the ability of Forskolin to augment cAMP levels in brain slices; antitussive.

Phthaleideisoquinoline alkaloid C22H23NO7 from plants of the Papaver genus, Papaveraceae.


PRICES
QuantityUS DollarsEURO
50 mg 53.20 38.00
250 mg 218.40 156.00


  • Molecular Weight : 413.14 Da.

  • Melting Point : 175-176 °C.

  • Solubility in : chloroform, not in water.

  • Purity min. : 98 % (TLC).

  • Biological Activity : Noscapine is an antitussive agent, acting on a Central Nervous System site. However, unlike Codeine and other narcotics, Noscapine lacks addictive, analgesic, respiratory depressant, and sedative properties. High affinity [3H]Noscapine binding sites are brain specific and ion insensitive. Although Noscapine (up to 1 mM) does not affect directly basal Phosphoinositide turnover or cAMP levels, it inhibits Carbachol-stimulated Phosphoinositide turnover (EC50 = 10 µM), and augments the stimulation by forskolin of cAMP levels (EC50 = 50 µM) (3).

  • Toxicity (LD50) : mice (orally): 1 090 mg/kg. mice (s.c.): 725 mg/kg. mice (i.v.): 47 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place.

  • CAS Reg. No. : 128-62-1

  • Merck Index 11th Ed. : 6638

  • Bibliography :
    1. Karlsson et al., "Characterization of high-affinity binding sites for the antitussive [3H]Noscapine in guinea pig brain tissue." Eur. J. Pharmacol. (1988). 145:195-203
    2. Mourey et al., "[3H]Noscapine binding sites in brain: relationship to indoleamines and the Phosphoinositide and adenylcyclase messenger systems." Molecular Pharmacology (1992). 42:619-626



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan