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Home Page > Alphabetical Index > NOSCAPINE

NOSCAPINE Prod. No L6093 - CAS # 128-62-1
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Product Name NOSCAPINE
(Syn.: Narcotine)
Product Code L6093
NOSCAPINE

C22H23NO7
Molecular Formula C22H23NO7
Description

an inhibitor of carbachol-stimulated phosphoinositide turnover; enhances the ability of Forskolin to augment cAMP levels in brain slices; antitussive.

Phthaleideisoquinoline alkaloid C22H23NO7 ‚ from plants of the Papaver genus‚ Papaveraceae.
 
Biological Activity

Noscapine is an antitussive agent‚ acting on a Central Nervous System site. However‚ unlike Codeine and other narcotics‚ Noscapine lacks addictive‚ analgesic‚ respiratory depressant‚ and sedative properties.
High affinity [3H]Noscapine binding sites are brain specific and ion insensitive.
Although Noscapine (up to 1 mM) does not affect directly basal Phosphoinositide turnover or cAMP levels‚ it inhibits Carbachol-stimulated Phosphoinositide turnover (EC50 = 10 µM)‚ and augments the stimulation by forskolin of cAMP levels
(EC50 = 50 µM) (3).
 
Chemical and Physical Properties
 
CAS No. 128-62-1 Molecular Weight 413.14 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 6638 Melting point 175-176 °C.
PubChem SID Solubility chloroform‚ not in water.
Purity 98 % (TLC). Optical Activity [a]D -202° ± 5° (chloroform).
Toxicity (LD50) mice (orally): 1 090 mg/kg.
mice (s.c.): 725 mg/kg.
mice (i.v.): 47 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Karlsson et al., "Characterization of high-affinity binding sites for the antitussive [3H]Noscapine in guinea pig brain tissue." Eur. J. Pharmacol. (1988). 145:195-203
  2. Mourey et al., "[3H]Noscapine binding sites in brain: relationship to indoleamines and the Phosphoinositide and adenylcyclase messenger systems." Molecular Pharmacology (1992). 42:619-626
 
Prices
Code
Quantity
US $
€uro
L6093
50 mg
53.20
38.00
250 mg
212.80
152.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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