Adrenergic and Serotonergic stimulant; CNS stimulant; antiarrhythmic.

C₂₀-diterpenoid alkaloid C₂₂H₃₁NO₃ from plants of the Aconitum genus, Ranunculaceae.

• Molecular Weight : 357 Da.
  
  
• Melting Point : 201-203° C.
  
  
• Solubility in : well in chloroform.
  
  
• Purity min. : 98 % (TLC, mass spectrometry, NMR).
  
  
• Biological Activity : antiarrhythmic and CNS stimulant; 25 times as potent as Quinidine and 2 times less toxic; the stimulant effect on the CNS is due to adrenergic and serotonergic stimulation in the reticular formation; causes desynchronization of cortex and sub-cortex action potential rhythms; enhances and prolongs the "reaction of activation" after visual and phonic stimulation; suppresses the electroencephalogram modifications due to intravenous injection of 2 mg/kg Chlorpromazine.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 142.5 mg/kg; mice (i.p.): 485 mg/kg; mice (s.c.): 630 mg/kg; mice (orally): 1 575 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place; solution for use: 10-8 M.
  
  
• CAS Reg. No. : 509-24-0
  
  
• Merck Index 11th Ed. : 8673
  
  
• Bibliography :
  
  1. De la Fuente et al., Heterocycles (1988). 27:1109