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Home Page > Alphabetical Index > SONGORINE

SONGORINE Prod. No L6097 - CAS # 509-24-0
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Product Name SONGORINE
Product Code L6097
SONGORINE

C22H31NO3
Molecular Formula C22H31NO3
Description

Adrenergic and Serotonergic stimulant; CNS stimulant; antiarrhythmic.

C20-diterpenoid alkaloid C22H31NO3 ‚ from plants of the Aconitum genus‚ Ranunculaceae.
 
Biological Activity

antiarrhythmic and CNS stimulant; 25 times as potent as Quinidine and 2 times less toxic; the stimulant effect on the CNS is due to adrenergic and serotonergic stimulation in the reticular formation; causes desynchronization of cortex and sub-cortex action potential rhythms; enhances and prolongs the "reaction of activation" after visual and phonic stimulation; suppresses the electroencephalogram modifications due to intravenous injection of 2 mg/kg Chlorpromazine.
 
Chemical and Physical Properties
 
CAS No. 509-24-0 Molecular Weight 357 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 8673 Melting point 201-203° C.
PubChem SID Solubility well in chloroform.
Purity 98 % (TLC‚ mass spectrometry‚ NMR). Optical Activity [a]D -140° (ethanol).
Toxicity (LD50) mice (i.v.): 142.5 mg/kg;
mice (i.p.): 485 mg/kg;
mice (s.c.): 630 mg/kg;
mice (orally): 1 575 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place; solution for use: 10-8 M.
Safety Recommendations
 
Bibliographic References
  1. De la Fuente et al., Heterocycles (1988). 27:1109
 
Prices
Code
Quantity
US $
€uro
L6097
5 mg
140.00
100.00
25 mg
560.00
400.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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