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Home Page > Alphabetical Index > TADJAKONINE

TADJAKONINE Prod. No L6098 - CAS # 11087-94-8
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Product Name TADJAKONINE
Product Code L6098
TADJAKONINE

C31H35NO7
Molecular Formula C31H35NO7
Description

antiarrhythmic; local anesthetic as potent as Cocaine.

C20-diterpenoid alkaloid C31H35NO7 ‚ from plants of the Ranunculaceae family.
 
Biological Activity

strong antiarrhythmic activity‚ and local anesthetic at least as potent as Cocaine; ED50 for arrhythmias caused by Aconitine: 0.3 mg/kg.
10-5 M block TTX-sensitive Na+ channels on rat isolated sensorial ganglion neurons (F. N. Djakhangirov and E. A. Valeev‚ unpublished).
 
Chemical and Physical Properties
 
CAS No. 11087-94-8 Molecular Weight 533.62 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point 248-249 °C. (decomp. acetone).
PubChem SID Solubility chloroform‚ moderately in ethanol; not well in acetone.
Purity 97 % (TLC‚ NMR‚ mass spectrometry). Optical Activity
Toxicity (LD50) rats (i.v.): 12.8 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations - for experiment on Tadjakonine local anesthetic activity: 0.25-0.5 % aqueous solution;
- for in vitro experiments: 10-9-10-8 M;
- to prepare a 1% aqueous solution of Tadjakonine: dissolve 20 mg of Tadjakonine in 0.3 ml 3 % HCl; dilute this solution in water up to obtaining 2 ml of total solution.
- Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Yussupova et al., Chem. Nat. Comp. (1992).p. 382
 
Prices
Code
Quantity
US $
€uro
L6098
20 mg
95.20
68.00
100 mg
380.80
272.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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