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Home Page > Alphabetical Index > IMPERIALINE (3-β-Bromo-)

IMPERIALINE (3-β-Bromo-) Prod. No L6099 - CAS # 176039-27-3
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Product Name IMPERIALINE (3-β-Bromo-)
Product Code L6099
IMPERIALINE (3-β-Bromo-)

C27H42NO2Br
Molecular Formula C27H42NO2Br
Description

M2 muscarinic receptor antagonist; myorelaxant; allows the production of 3-α-[125I]Iodo-Imperialine by substitution of bromine by [125I] iodine.

Steroid alkaloid C27H42NO2Br derivative of Imperialine from the plant Petilium eduardi‚ and P. raddeanae.
 
Biological Activity

Possesses M2 selective activity. ED50 on cats under anaesthesia (i.v.) 0.015 mg/kg : 65% of Atropine activity on heart‚ 1.7% on isolated ileum‚ 0.16% on salivary gland.
Anti-depolarising myorelaxant.
At sublethal doses: muscular weakness‚ irregular and slow respiration‚ exophthalm‚ depression.Effects diminished after 10-15 min‚ recovery after 60 min.
 
Chemical and Physical Properties
 
CAS No. 176039-27-3 Molecular Weight 492 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 4840 Melting point 199-202°C.
PubChem SID Solubility well in chloroform; slightly in methanol and ethanol; not well in acetone.
Purity 98 % (TLC). Optical Activity
Toxicity (LD50) mice (i.v.): 48 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place.
Safety Recommendations
 
Bibliographic References
  1. Eglen et al., "Characterisation of the interaction of the cervane alkaloid, imperialine, at Muscarinic receptors in vitro." Naunyn-Schmiedeberg’s Arch. Pharmacol. (1992) 346:144-152
  2. on 3-b-Bromo-Imperialine: Mirzaev, unbublished results.
 
Prices
Code
Quantity
US $
€uro
L6099
1 x 1 mg
449.40
321.00
5 x 1 mg
1 797.60
1 284.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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