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Home Page > Alphabetical Index > STROPHANTIDIN ACETATE

STROPHANTIDIN ACETATE Prod. No L6205 - CAS # 60-38-8
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Product Name STROPHANTIDIN ACETATE
Product Code L6205
STROPHANTIDIN ACETATE

C25H34O7
Molecular Formula C25H34O7
Description

an ATPase inhibitor‚ cardiotonic.

Cardiac glycoside C25H34O7 derivative of Strophantidin from plants of the Strophantus genus‚ Apocynaceae.
 
Biological Activity

IC50 for cardiac Na+/K+-ATPase inhibition: 0.4 µM;

IC50 for renal Na+/K+-ATPase inhibition: 1.3 µM;
 
Chemical and Physical Properties
 
CAS No. 60-38-8 Molecular Weight 446.5 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 8818 Melting point 238-242 °C. (decomp.).
PubChem SID Solubility chloroform; slightly in ethanol; not in water and ether.
Purity 98 % (TLC). Optical Activity [a]D + 52°.
Toxicity (LD50) cat (i.v.): 0.3 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Store at +4°C‚ in dark place; solution for use: 0.05%.
Safety Recommendations
 
Bibliographic References
  1. Kai Yuan Yu, "Inhibition of H+-transporting ATPase, Ca2+-transporting ATPase and H+/K+-transporting ATPase by Strophantidin." Biochim. Biophys. Acta (1992). 1159(1):109-112
  2. Mirsalichova et al., "The thermodynamic essence of the reversible inactivation of Na+/K+ transporting ATPase by various digitalis derivatives is relaxation of enzyme conformational energy." Bioch. Biophys. Acta (1988). 937:335-346
 
Prices
Code
Quantity
US $
€uro
L6205
5 mg
51.80
37.00
25 mg
207.20
148.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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