an ATPase inhibitor, cardiotonic.

Cardiac glycoside C₂₅H₃₄O₇ derivative of Strophantidin from plants of the Strophantus genus, Apocynaceae.

• Molecular Weight : 446.5 Da.
  
  
• Melting Point : 238-242 °C. (decomp.).
  
  
• Solubility in : chloroform; slightly in ethanol; not in water and ether.
  
  
• Purity min. : 98 % (TLC).
  
  
• Biological Activity : IC₅₀ for cardiac Na⁺/K⁺-ATPase inhibition: 0.4 µM;
  IC₅₀ for renal Na⁺/K⁺-ATPase inhibition: 1.3 µM;
  
  
• Toxicity (LD₅₀) : cat (i.v.): 0.3 mg/kg.
  
  
• Storage recommendations : Store at +4°C, in dark place; solution for use: 0.05%.
  
  
• CAS Reg. No. : 60-38-8
  
  
• Merck Index 11th Ed. : 8818
  
  
• Bibliography :
  
  1. Kai Yuan Yu, "Inhibition of H+-transporting ATPase, Ca2+-transporting ATPase and H+/K+-transporting ATPase by Strophantidin." Biochim. Biophys. Acta (1992). 1159(1):109-112
  2. Mirsalichova et al., "The thermodynamic essence of the reversible inactivation of Na+/K+ transporting ATPase by various digitalis derivatives is relaxation of enzyme conformational energy." Bioch. Biophys. Acta (1988). 937:335-346