STROPHANTIDIN ACETATE - LATOXAN Technical Data Sheet
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L6205 STROPHANTIDIN ACETATE

an ATPase inhibitor, cardiotonic.

Cardiac glycoside C25H34O7 derivative of Strophantidin from plants of the Strophantus genus, Apocynaceae.


PRICES
QuantityUS DollarsEURO
5 mg 51.80 37.00
25 mg 207.20 148.00


  • Molecular Weight : 446.5 Da.

  • Melting Point : 238-242 °C. (decomp.).

  • Solubility in : chloroform; slightly in ethanol; not in water and ether.

  • Purity min. : 98 % (TLC).

  • Biological Activity : IC50 for cardiac Na+/K+-ATPase inhibition: 0.4 µM;
    IC50 for renal Na+/K+-ATPase inhibition: 1.3 µM;

  • Toxicity (LD50) : cat (i.v.): 0.3 mg/kg.

  • Storage recommendations : Store at +4°C, in dark place; solution for use: 0.05%.

  • CAS Reg. No. : 60-38-8

  • Merck Index 11th Ed. : 8818

  • Bibliography :
    1. Kai Yuan Yu, "Inhibition of H+-transporting ATPase, Ca2+-transporting ATPase and H+/K+-transporting ATPase by Strophantidin." Biochim. Biophys. Acta (1992). 1159(1):109-112
    2. Mirsalichova et al., "The thermodynamic essence of the reversible inactivation of Na+/K+ transporting ATPase by various digitalis derivatives is relaxation of enzyme conformational energy." Bioch. Biophys. Acta (1988). 937:335-346



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    Revised : 26/04/2007 10:28 - Copyright © Latoxan