Nicotinic receptor antagonist at the neuromuscular junction and vegetative ganglia; hypotensive.

Diterpene alkaloid C₂₅H₃₉NO₇ from plants of the Delphinium genus, Ranunculaceae.

• Molecular Weight : 465 Da.
  
  
• Melting Point : 158-159 °C (ethanol), 167-168 °C (acetone).
  
  
• Solubility in : chloroform.
  
  
• Purity min. : 99% mass spectrometry, RMN, IR, TLC [aluminium oxide, chloroform:methanol (100:1)]
  
  
• Physical Form : white crystal powder.
  
  
• Biological Activity : Blocks the propagation of the action potential at the nicotinic cholinoreceptors of vegetative ganglia and neuro-muscular junctions.
  Hypotensive and curare-like action, i.v. and orally.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 18 mg/kg
  
  
• Storage recommendations : Stable in dry state, store at +4°C, in dark place.
  Solution for use in vitro: 10^-7 M-10^-5 M; dose for one experiment in vivo: 2-7 mg/kg (i.v.).
  
  
• CAS Reg. No. : 71609-79-5
  
  
• Bibliography :
  
  1. Vaisov et al., Chem. Nat. Comp. (1986). (Russian). 6:801
  2. Pelletier et al., Heterocycles (1979). 12:779
  3. Djahangirov: unpublished.