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Home Page > Alphabetical Index > NAPELLINE

NAPELLINE Prod. No L6215 - CAS # 5008-52-6
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Product Name NAPELLINE
(Syn.: Luciculine)
Product Code L6215
NAPELLINE

C22H33NO3
Molecular Formula C22H33NO3
Description

Potent antiarrhythmic (class I)‚ with weak hypotensive and N-cholinoblocking effects.

Diterpenoid alkaloid C22H33NO3 ‚ from plants of the Aconitum genus‚ Ranunculaceae
 
Biological Activity

Napelline has a stronger antiarrhythmic activity than Quinidine or Procaïnamide.
10-4 - 10-5 M block inward Na+ currents.[3]
 
Chemical and Physical Properties
 
CAS No. 5008-52-6 Molecular Weight 359 Da.
RTECS Physical Form yellowish crystal powder.
Merck Index No (13th Ed.) 6286 Melting point 162-164 °C
PubChem SID Solubility well in chloroform; moderately in acetone and methanol; not well in water.
Purity 91%. TLC [silicagel‚ chloroform:methanol (9:1)] Optical Activity
Toxicity (LD50) mice (i.v.) : 87.5 mg/kg
mice (i.p.) : 280 mg/kg
Chemical Names
Storage & Reconstitution Recommendations Stable in dry state; store at 4°C‚ in dark place. Solutions for experiments in vitro: 10-6 to 10-5 M; doses for one experiment in vivo: 10-20 mg/kg.
Safety Recommendations
 
Bibliographic References
  1. "The Alkaloids" R.H.F. Manske Ed. (Academic Press Inc., New-York) (1955). 4:291
  2. Okamoto et al., Chem. and Pharm. Bull. (1965) (Japan). 13:1270
  3. Djahangirov et al., "Pharmacology of the alkaloids Napelline and Heteratisine" Rpts. Acad. Sciences Uzb. (1977) (Russian). 3:50-51
 
Prices
Code
Quantity
US $
€uro
L6215
20 mg
134.40
96.00
100 mg
537.60
384.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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