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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L6215 NAPELLINE
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| ( Luciculine ) |
Potent antiarrhythmic (class I), with weak hypotensive and N-cholinoblocking effects.
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Diterpenoid alkaloid C22H33NO3 from plants of the Aconitum genus, Ranunculaceae
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| PRICES |
| Quantity | US Dollars | EURO |
20 mg | 134.40 | 96.00 |
100 mg | 537.60 | 384.00 |
- Molecular Weight : 359 Da.
- Melting Point : 162-164 °C
- Solubility in : well in chloroform; moderately in acetone and methanol; not well in water.
- Purity min. : 91%. TLC [silicagel, chloroform:methanol (9:1)]
- Physical Form : yellowish crystal powder.
- Biological Activity : Napelline has a stronger antiarrhythmic activity than Quinidine or Procaïnamide.
10-4 - 10-5 M block inward Na+ currents.[3]
- Toxicity (LD50) : mice (i.v.) : 87.5 mg/kg
mice (i.p.) : 280 mg/kg
- Storage recommendations : Stable in dry state; store at 4°C, in dark place. Solutions for experiments in vitro: 10-6 to 10-5 M; doses for one experiment in vivo: 10-20 mg/kg.
- CAS Reg. No. : 5008-52-6
- Merck Index 11th Ed. : 6286
- Bibliography :
- "The Alkaloids" R.H.F. Manske Ed. (Academic Press Inc., New-York) (1955). 4:291
- Okamoto et al., Chem. and Pharm. Bull. (1965) (Japan). 13:1270
- Djahangirov et al., "Pharmacology of the alkaloids Napelline and Heteratisine" Rpts. Acad. Sciences Uzb. (1977) (Russian). 3:50-51
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