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Home Page > Alphabetical Index > LYCACONITINE PERCHLORATE

LYCACONITINE PERCHLORATE Prod. No L6221 - CAS # 321938-55-0
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Product Name LYCACONITINE PERCHLORATE
Product Code L6221
LYCACONITINE PERCHLORATE

C36H48N2O10.HClO4

Molecular Formula C36H48N2O10.HClO4
Description

a nicotinic receptor antagonist at the neuromuscular junction; ganglioblocker; potent medium-acting muscle relaxant and hypotensive.

C19-norditerpenoid alkaloid C36H48N2O10.HClO4 purified from plants of the Aconitum genus‚ Ranunculacae.

 
Biological Activity

Good penetration of the blood-tissue barrier.
Acts on nicotinic cholinoreceptors of the Peripheral and Central Nervous Systems‚ whatever the way of administering in vivo.


On cat under anaesthesia‚ 1.5 mg/kg (i.v.) or 30 mg/kg (orally) block the activity of N-cholinoreceptors at the neuromuscular junction.10-5 g/ml block the neuromuscular transmission on the rat diaphragm preparation.


0.5-2 mg/kg (i.v.) on cat under anaesthesia‚ cause hypotension due to the blockade of the transmission of nervous impulses in sympathetic and orthosympathetic ganglia.


Belongs to the family of non depolarizing myorelaxant. Antagonists: Proserine‚ Galanthamine.

 
Chemical and Physical Properties
 
CAS No. 321938-55-0 Molecular Weight 768 Da.
RTECS Physical Form cream-white crystal.
Merck Index No (13th Ed.) Melting point 184-186 °C (ethanol; forming foam); softens at 170°C.
PubChem SID Solubility moderately in water and methanol; not well in ethanol.
Purity IR‚ NMR‚ TLC [aluminium oxide‚ benzene:ethanol (20:1)]‚ TLC [silicagel‚ benzene:ethanol (9:1) ]‚ melting point. Optical Activity
Toxicity (LD50) mice (orally) : 31 mg/kg.
mice (i.v.) : 2.6 mg/kg.
mice (i.p.): 12.5 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations Stable in dry state‚ store at + 4°C‚ in dark place. Solution for experiments in vitro: 10-5 - 10-7 M; doses for experiments in vivo on cats and dogs: 1-3 mg/kg (i.v.) or 20-30 mg/kg (orally).
Safety Recommendations
 
Bibliographic References
  1. Pelletier et al., J. Am. Chem. Soc.(1981) 103:6536-6538
  2. Shamma et al., J. Nat. Prod. (1979). 42:615-623
  3. Djahangirov, "About the pharmacology of the alkaloid Lycaconitine." Problems of Pharmacology and Pharmacy, Tashkent (1976) (Russian). 4: 21-22
 
Prices
Code
Quantity
US $
€uro
L6221
10 mg
127.40
91.00
50 mg
509.60
364.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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