 |


ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

|
|

| | L6221 LYCACONITINE PERCHLORATE
|
a nicotinic receptor antagonist at the neuromuscular junction; ganglioblocker; potent medium-acting muscle relaxant and hypotensive.
|
C19-norditerpenoid alkaloid C36H48N2O10.HClO4 purified from plants of the Aconitum genus, Ranunculacae.
|

| PRICES |
| Quantity | US Dollars | EURO |
10 mg | 127.40 | 91.00 |
50 mg | 509.60 | 364.00 |
- Molecular Weight : 768 Da.
- Melting Point : 184-186 °C (ethanol; forming foam); softens at 170°C.
- Solubility in : moderately in water and methanol; not well in ethanol.
- Purity min. : IR, NMR, TLC [aluminium oxide, benzene:ethanol (20:1)], TLC [silicagel, benzene:ethanol (9:1) ], melting point.
- Physical Form : cream-white crystal.
- Biological Activity : Good penetration of the blood-tissue barrier.
Acts on nicotinic cholinoreceptors of the Peripheral and Central Nervous Systems, whatever the way of administering in vivo.
On cat under anaesthesia, 1.5 mg/kg (i.v.) or 30 mg/kg (orally) block the activity of N-cholinoreceptors at the neuromuscular junction.10-5 g/ml block the neuromuscular transmission on the rat diaphragm preparation.
0.5-2 mg/kg (i.v.) on cat under anaesthesia, cause hypotension due to the blockade of the transmission of nervous impulses in sympathetic and orthosympathetic ganglia.
Belongs to the family of non depolarizing myorelaxant. Antagonists: Proserine, Galanthamine.
- Toxicity (LD50) : mice (orally) : 31 mg/kg.
mice (i.v.) : 2.6 mg/kg.
mice (i.p.): 12.5 mg/kg.
- Storage recommendations : Stable in dry state, store at + 4°C, in dark place. Solution for experiments in vitro: 10-5 - 10-7 M; doses for experiments in vivo on cats and dogs: 1-3 mg/kg (i.v.) or 20-30 mg/kg (orally).
- CAS Reg. No. : 321938-55-0
- Bibliography :
- Pelletier et al., J. Am. Chem. Soc.(1981) 103:6536-6538
- Shamma et al., J. Nat. Prod. (1979). 42:615-623
- Djahangirov, "About the pharmacology of the alkaloid Lycaconitine." Problems of Pharmacology and Pharmacy, Tashkent (1976) (Russian). 4: 21-22
|
|
Latoxan - 20, Rue Léon Blum - F-26000 VALENCE - France Phone: +33.4.75.41.91.91 - Fax: +33.4.75.41.91.99
contact@latoxan.com
For Research Purposes Only - Not for Human Use. |
Revised : 26/04/2007 10:27 - Copyright © Latoxan |
|