a nicotinic receptor antagonist at the neuromuscular junction; ganglioblocker; potent medium-acting muscle relaxant and hypotensive.

C₁₉-norditerpenoid alkaloid C₃₆H₄₈N₂O₁₀.HClO₄ purified from plants of the Aconitum genus‚ Ranunculacae.

Good penetration of the blood-tissue barrier.
Acts on nicotinic cholinoreceptors of the Peripheral and Central Nervous Systems‚ whatever the way of administering in vivo.


On cat under anaesthesia‚ 1.5 mg/kg (i.v.) or 30 mg/kg (orally) block the activity of N-cholinoreceptors at the neuromuscular junction.10-5 g/ml block the neuromuscular transmission on the rat diaphragm preparation.


0.5-2 mg/kg (i.v.) on cat under anaesthesia‚ cause hypotension due to the blockade of the transmission of nervous impulses in sympathetic and orthosympathetic ganglia.


Belongs to the family of non depolarizing myorelaxant. Antagonists: Proserine‚ Galanthamine.

1. Pelletier et al., J. Am. Chem. Soc.(1981) 103:6536-6538
2. Shamma et al., J. Nat. Prod. (1979). 42:615-623
3. Djahangirov, "About the pharmacology of the alkaloid Lycaconitine." Problems of Pharmacology and Pharmacy, Tashkent (1976) (Russian). 4: 21-22