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Home Page > Alphabetical Index > CARDIOTOXIN

CARDIOTOXIN Prod. No L8102 - CAS # 11061-96-4
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Product Name CARDIOTOXIN
(Syn.: Cytotoxin)
Product Code L8102
CARDIOTOXIN
Molecular Formula
Description

a protein kinase C specific inhibitor‚ with an IC50 of 1-3 µM; depolarizes the skeletal muscle fibres in vitro.

60-amino acid peptide with 4 disulfide bridges ‚ from Naja nigricollis snake venom.
 
Biological Activity

 
Chemical and Physical Properties
 
CAS No. 11061-96-4 Molecular Weight 6‚800 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID 3732219 Solubility well in water and saline.
Purity 95 %.(isoelectrofocusing‚ HPLC); Phospholipase A2 activity < 2%. Optical Activity
Toxicity (LD50) (LD100) mice (i.v.): 1.5-1.7 mg/kg.
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state; in solution‚ keep at -20°C.
Safety Recommendations
 
Bibliographic References
  1. Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 32(8):2062-2067
  2. Fletcher et al., "Possible mechanisms of Action of cobra snake venom cardiotoxins and bee venom melittin." Toxicon 1993 31(6):669-695
  3. Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5): 2753-2758
  4. D'Albis et al., "Regeneration after cardiotoxin injury of innervated and denervated slow and fast muscles of mammals." Eur. J. Biochem. 1988 174:103-110
  5. Grognet et al., Molecular Immunology 1986 23(12):1329-1337
  6. Fryklund et al., Biochemistry 1975 14:2865
 
Prices
Code
Quantity
US $
€uro
L8102
1 x 1 mg
211.40
151.00
5 x 1 mg
845.60
604.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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