NOTEXIN Np - LATOXAN Technical Data Sheet
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ION CHANNEL and RECEPTOR LIGANDS
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L8104 NOTEXIN Np

a toxic presynaptic PLA2 with potent myotoxic activity; HPLC pure.

119-amino acid protein from Notechis scutatus snake venom.

PRICES
QuantityUS DollarsEURO
100 µg 231.00 165.00
5 x 100 µg 924.00 660.00


  • Molecular Weight : 13,574 Da.

  • Solubility in : well in water and saline.

  • Purity min. : 93% (HPLC).
    Notexin, purified according to Karlsson et al. (1) from the venom of snakes collected near Sydney, was shown by HPLC (2, 4) to be composed of several components, which are structurally and functionally very similar:
    - Notexin Np and
    - Notechis Ns, a minor natural variant

  • Biological Activity : Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities (1, 3).

  • Toxicity (LD50) : minimal L.D. is 25 µg/kg mouse when injected intraveinously (1)

  • Storage recommendations : stable in freeze-dried state. In solution, keep at -20 °C.

  • CAS Reg. No. : 37223-96-4

  • Bibliography :
    1. Karlsson et al. Toxicon (1972). 10:405-413
    2. Mollier et al. Eur. J. Biochem. (1989). 185:263-270
    3. Halpert et al., J. Biol. Chem. (1975). 250:6990-6997
    4. Chwetzoff et al., FEBS Letters (1990). 161(2):226-230



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    Revised : 04/06/2007 10:50 - Copyright © Latoxan