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NOTEXIN NP Prod. No L8104 - CAS # 37223-96-4
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Product Name NOTEXIN NP
Product Code L8104
NOTEXIN NP
Molecular Formula
Description

a toxic presynaptic PLA2 with potent myotoxic activity; HPLC pure.

119-amino acid protein ‚ from Notechis scutatus snake venom.
 
Biological Activity

Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities (1‚ 3).
 
Chemical and Physical Properties
 
CAS No. 37223-96-4 Molecular Weight 13‚574 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity 93% (HPLC).
Notexin‚ purified according to Karlsson et al. (1) from the venom of snakes collected near Sydney‚ was shown by HPLC (2‚ 4) to be composed of several components‚ which are structurally and functionally very similar:

- Notexin Np and

- Notechis Ns‚ a minor natural variant		 Optical Activity
Toxicity (LD50) minimal L.D. is 25 µg/kg mouse when injected intraveinously (1)
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state. In solution‚ keep at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Karlsson et al. Toxicon (1972). 10:405-413
  2. Mollier et al. Eur. J. Biochem. (1989). 185:263-270
  3. Halpert et al., J. Biol. Chem. (1975). 250:6990-6997
  4. Chwetzoff et al., FEBS Letters (1990). 161(2):226-230
 
Prices
Code
Quantity
US $
€uro
L8104-100UG
1 x 100 µg
231.00
165.00
5 x 100 µg
924.00
660.00
L8104-500UG
1 x 500 µg
924.00
660.00
5 x 500 µg
3 696.00
2 640.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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