a toxic presynaptic PLA₂ with potent myotoxic activity; HPLC pure.

119-amino acid protein from Notechis scutatus snake venom.

• Molecular Weight : 13,574 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : 93% (HPLC).
  Notexin, purified according to Karlsson et al. (1) from the venom of snakes collected near Sydney, was shown by HPLC (2, 4) to be composed of several components, which are structurally and functionally very similar:
  - Notexin Np and
  - Notechis Ns, a minor natural variant
  
  
• Biological Activity : Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities (1, 3).
  
  
• Toxicity (LD₅₀) : minimal L.D. is 25 µg/kg mouse when injected intraveinously (1)
  
  
• Storage recommendations : stable in freeze-dried state. In solution, keep at -20 °C.
  
  
• CAS Reg. No. : 37223-96-4
  
  
• Bibliography :
  
  1. Karlsson et al. Toxicon (1972). 10:405-413
  2. Mollier et al. Eur. J. Biochem. (1989). 185:263-270
  3. Halpert et al., J. Biol. Chem. (1975). 250:6990-6997
  4. Chwetzoff et al., FEBS Letters (1990). 161(2):226-230