a toxic presynaptic Phospholipase A₂ also referred to as toxin "k₂".

122- amino acid protein with 7 disulfide bridges from Vipera ammodytes snake venom.

• Molecular Weight : 13,775 Da.
  
  
• Solubility in : well in water and saline.
  Purification: gel filtration on Sephadex G-100 and ion exchange chromotography on CM-cellulose.
  
  
• Biological Activity : mode of action (4): blocks neuromuscular transmission by acting selectively at the presynaptic site.
  
  
• Toxicity (LD₅₀) : mice (i.v.): 0.021 mg/kg (3).
  
  
• Storage recommendations : stable in freeze-dried state. In solution, keep at -20°C.
  
  
• CAS Reg. No. : 97089-72-0
  
  
• Bibliography :
  
  1. Gubensek et al., Period. Biol. (1980). 82:444-447
  2. Ritonja et al., Biochimica et Biophysica Acta (1985). 828:306-312
  3. Thouin et al., Toxicon, (1982) 20:1051-1058
  4. Lee, C.Y., Tsai, M.C., Chen, Y.M., Ritonja, A. & Gubensek, F., Arch. Int. Pharmacodyn., 268, 313-324.