a toxin which facilitates synaptic transmission at the neuromuscular junction (1) and has been shown to block a 4-AP-sensitive, inactivating, voltage-gated K⁺ current (2-3).

59-amino acid peptide with 3 disulfide bridges from Dendroaspis angusticeps snake venom.

• Molecular Weight : 7,048 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : 98% (HPLC).
  Mode of purification:
  the venom was fractionated by the method of Harvey and Karlsson; the fraction containing Alpha–Dendrotoxin was purified by HPLC.
  
  
• Storage recommendations : stable in freeze-dried state. In solution, keep at -20°C.
  
  
• CAS Reg. No. : 74504-53-3
  
  
• Bibliography :
  
  1. Harvey et al., "Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctionnal blocking toxins." Br. J. Pharmacol. 1982 77:153-161
  2. Halliwell et al., "Central action of Dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors." Proc. Natl. Acad. Sci. USA (1986). 83:493-497
  3. Stansfeld et al., "4-Aminopyridine and Dendrotoxin induce repetitive firing in rat visceral sensory neurons by blocking slowly inactivating outward current." Neurosci. Lett.(1986). 64:299-304
  4. Harvey et al., "Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps: a neurotoxin that enhances acetylcholine release at neuromuscular junctions." Naunyn-Schmiedeberg's Arch. Pharmacol. (1980). 312:1-6
  5. Benishin et al., Molecular Pharmacology(1988). 34:152-159