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Home Page > Alphabetical Index > DENDROTOXIN (α-)

DENDROTOXIN (α-) Prod. No L8106 - CAS # 74504-53-3
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Product Name DENDROTOXIN (α-)
Product Code L8106
DENDROTOXIN (α-)
Molecular Formula
Description

a toxin which facilitates synaptic transmission at the neuromuscular junction (1) and has been shown to block a 4-AP-sensitive‚ inactivating‚ voltage-gated K+ current (2-3).

59-amino acid peptide with 3 disulfide bridges ‚ from Dendroaspis angusticeps snake venom.
 
Biological Activity

 
Chemical and Physical Properties
 
CAS No. 74504-53-3 Molecular Weight 7‚048 Da.
RTECS Physical Form
Merck Index No (13th Ed.) Melting point
PubChem SID Solubility well in water and saline.
Purity 98% (HPLC).
Mode of purification:

the venom was fractionated by the method of Harvey and Karlsson; the fraction containing Alpha–Dendrotoxin was purified by HPLC.		 Optical Activity
Toxicity (LD50)
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state. In solution‚ keep at -20°C.
Safety Recommendations
 
Bibliographic References
  1. Harvey et al., "Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctionnal blocking toxins." Br. J. Pharmacol. 1982 77:153-161
  2. Halliwell et al., "Central action of Dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors." Proc. Natl. Acad. Sci. USA (1986). 83:493-497
  3. Stansfeld et al., "4-Aminopyridine and Dendrotoxin induce repetitive firing in rat visceral sensory neurons by blocking slowly inactivating outward current." Neurosci. Lett.(1986). 64:299-304
  4. Harvey et al., "Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps: a neurotoxin that enhances acetylcholine release at neuromuscular junctions." Naunyn-Schmiedeberg's Arch. Pharmacol. (1980). 312:1-6
  5. Benishin et al., Molecular Pharmacology(1988). 34:152-159
 
Prices
Code
Quantity
US $
€uro
L8106
1 x 100 µg
191.80
137.00
5 x 100 µg
767.20
548.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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