DENDROTOXIN - LATOXAN Technical Data Sheet
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L8106 aDENDROTOXIN

a toxin which facilitates synaptic transmission at the neuromuscular junction (1) and has been shown to block a 4-AP-sensitive, inactivating, voltage-gated K+ current (2-3).

59-amino acid peptide with 3 disulfide bridges from Dendroaspis angusticeps snake venom.


PRICES
QuantityUS DollarsEURO
100 µg 191.80 137.00
5 x 100 µg 767.20 548.00


  • Molecular Weight : 7,048 Da.

  • Solubility in : well in water and saline.

  • Purity min. : 98% (HPLC).
    Mode of purification:
    the venom was fractionated by the method of Harvey and Karlsson; the fraction containing Alpha–Dendrotoxin was purified by HPLC.

  • Storage recommendations : stable in freeze-dried state. In solution, keep at -20°C.

  • CAS Reg. No. : 74504-53-3

  • Bibliography :
    1. Harvey et al., "Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctionnal blocking toxins." Br. J. Pharmacol. 1982 77:153-161
    2. Halliwell et al., "Central action of Dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors." Proc. Natl. Acad. Sci. USA (1986). 83:493-497
    3. Stansfeld et al., "4-Aminopyridine and Dendrotoxin induce repetitive firing in rat visceral sensory neurons by blocking slowly inactivating outward current." Neurosci. Lett.(1986). 64:299-304
    4. Harvey et al., "Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps: a neurotoxin that enhances acetylcholine release at neuromuscular junctions." Naunyn-Schmiedeberg's Arch. Pharmacol. (1980). 312:1-6
    5. Benishin et al., Molecular Pharmacology(1988). 34:152-159



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan