an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction; differs from L81 11 Eraburoxin b with an asparagine at residue 26.

62-amino acid peptide with 4 disulfide bridges ‚ from Laticauda semifasciata snake venom.

Erabutoxin a is a reversible nicotinic receptor antagonist;
binding to the acetylcholine receptors of Torpedo marmorata electric organs:
Kd = 10-10 M. (3)

1. Tamiya et al., Biochem. J. (1966). 99:624
2. Ishikawa et al., "Current view of the structure-function relationship of postsynaptic neurotoxins from snake venoms." Toxicon (1977). 15:477
3. Chiappinelli et al., Brain Res. (1981). 211:107
4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451