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Home Page > Alphabetical Index > ERABUTOXIN b

ERABUTOXIN b Prod. No L8111 - CAS # 9083-23-2
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Product Name ERABUTOXIN b
Product Code L8111
ERABUTOXIN b
Molecular Formula
Description

an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction; differs from L81 10 Eraburoxin a with an histidine at residue 26.

62-amino acid peptide with 4 disulfide bridges ‚ from Laticauda semifasciata snake venom.
 
Biological Activity

Erabutoxin b is a reversible nicotinic receptor antagonist;
binding to the acetylcholine receptors of Torpedo marmorata electric organs:
Kd = 4 x 10-11 M. (3)
 
Chemical and Physical Properties
 
CAS No. 9083-23-2 Molecular Weight 6‚852 Da.
RTECS Physical Form
Merck Index No (13th Ed.) 3584 Melting point
PubChem SID Solubility well in water and saline.
Purity salt-free‚ freeze-dried preparation; homogeneous (CM-cellulose & gel-chromatography). Optical Activity
Toxicity (LD50) mice (i.m.): 0.15 mg/kg. (2)
Chemical Names
Storage & Reconstitution Recommendations stable in freeze-dried state; store in dark and cold place; in solution‚ keep store at -20 °C.
Safety Recommendations
 
Bibliographic References
  1. Tamiya et al., Biochem. J. (1966). 99:624
  2. Ishikawa et al., "Current view of the structure-function relationship of postsynaptic neurotoxins from snake venoms." Toxicon (1977). 15:477
  3. Chiappinelli et al., Brain Res. (1981). 211:107
  4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451
 
Prices
Code
Quantity
US $
€uro
L8111
1 x 1 mg
145.60
104.00
5 x 1 mg
582.40
416.00
 
External Links PubMed Biomedical Citations From PubMed Toxicology Citations From PubMed PubChem SID

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