an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction; differs from L81 10 Eraburoxin a with an histidine at residue 26.

62-amino acid peptide with 4 disulfide bridges from Laticauda semifasciata snake venom.

• Molecular Weight : 6,852 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : salt-free, freeze-dried preparation; homogeneous (CM-cellulose & gel-chromatography).
  
  
• Biological Activity : Erabutoxin b is a reversible nicotinic receptor antagonist; binding to the acetylcholine receptors of Torpedo marmorata electric organs: Kd = 4 x 10-11 M. (3)
  
  
• Toxicity (LD₅₀) : mice (i.m.): 0.15 mg/kg. (2)
  
  
• Storage recommendations : stable in freeze-dried state; store in dark and cold place; in solution, keep store at -20 °C.
  
  
• CAS Reg. No. : 9083-23-2
  
  
• Merck Index 11th Ed. : 3584
  
  
• Bibliography :
  
  1. Tamiya et al., Biochem. J. (1966). 99:624
  2. Ishikawa et al., "Current view of the structure-function relationship of postsynaptic neurotoxins from snake venoms." Toxicon (1977). 15:477
  3. Chiappinelli et al., Brain Res. (1981). 211:107
  4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451