ERABUTOXIN b - LATOXAN Technical Data Sheet
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L8111 ERABUTOXIN b
- Buffer-Free -

an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction; differs from L81 10 Eraburoxin a with an histidine at residue 26.

62-amino acid peptide with 4 disulfide bridges from Laticauda semifasciata snake venom.


PRICES
QuantityUS DollarsEURO
1 mg 145.60 104.00
5 x 1 mg 582.40 416.00


  • Molecular Weight : 6,852 Da.

  • Solubility in : well in water and saline.

  • Purity min. : salt-free, freeze-dried preparation; homogeneous (CM-cellulose & gel-chromatography).

  • Biological Activity : Erabutoxin b is a reversible nicotinic receptor antagonist; binding to the acetylcholine receptors of Torpedo marmorata electric organs: Kd = 4 x 10-11 M. (3)

  • Toxicity (LD50) : mice (i.m.): 0.15 mg/kg. (2)

  • Storage recommendations : stable in freeze-dried state; store in dark and cold place; in solution, keep store at -20 °C.

  • CAS Reg. No. : 9083-23-2

  • Merck Index 11th Ed. : 3584

  • Bibliography :
    1. Tamiya et al., Biochem. J. (1966). 99:624
    2. Ishikawa et al., "Current view of the structure-function relationship of postsynaptic neurotoxins from snake venoms." Toxicon (1977). 15:477
    3. Chiappinelli et al., Brain Res. (1981). 211:107
    4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451



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    Revised : 26/04/2007 10:27 - Copyright © Latoxan