an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.

66-amino acid peptide with 5 disulfide bridges ‚ from Laticauda semifasciata snake venom.

nicotinic receptor antagonist‚ with a reversible binding to the receptor (its affinity is 1/40th that of Erabutoxin b).

binding to the acetylcholine receptors of Torpedo marmorata electric organs:

Kd = 1.6 x 10-9 M. (3)

1. Tamiya et al., "Studies on sea-snake venoms: crystallization of Erabutoxins a and b from Laticauda semifasciata venom." Biochem. J. (1966). 99:624-630
2. Ishikawa et al., "Structures of snake toxins and their affinity to the acetylcholine receptor of fish electric organ." Toxicon (1977). 15:477-488
3. Chiappinelli et al., "The effects of a- and b- neurotoxins from the venoms of various snakes on transmission in autonomic ganglia." Brain Res. (1981). 211:107-126
4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451