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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8112 LATICAUDA SEMIFASCIATA III
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| ( Ls III ) |
| - Buffer-Free - |
an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.
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66-amino acid peptide with 5 disulfide bridges from Laticauda semifasciata snake venom.
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| PRICES |
| Quantity | US Dollars | EURO |
1 mg | 201.60 | 144.00 |
5 x 1 mg | 806.40 | 576.00 |
- Molecular Weight : 7,229 Da.
- Solubility in : well in water and saline.
- Purity min. : salt-free, freeze-dried preparation; homogeneous (CM-cellulose & gel-chromatography).
- Biological Activity : nicotinic receptor antagonist, with a reversible binding to the receptor (its affinity is 1/40th that of Erabutoxin b).
binding to the acetylcholine receptors of Torpedo marmorata electric organs:
Kd = 1.6 x 10-9 M. (3)
- Toxicity (LD50) : mice (i.m.): 0.85 mg/kg. (2)
- Storage recommendations : stable in freeze-dried state; keep in dark and cold place; in solution, keep at -20 °C.
- CAS Reg. No. : 75433-28-2
- Bibliography :
- Tamiya et al., "Studies on sea-snake venoms: crystallization of Erabutoxins a and b from Laticauda semifasciata venom." Biochem. J. (1966). 99:624-630
- Ishikawa et al., "Structures of snake toxins and their affinity to the acetylcholine receptor of fish electric organ." Toxicon (1977). 15:477-488
- Chiappinelli et al., "The effects of a- and b- neurotoxins from the venoms of various snakes on transmission in autonomic ganglia." Brain Res. (1981). 211:107-126
- Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451
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