an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.

66-amino acid peptide with 5 disulfide bridges from Laticauda semifasciata snake venom.

• Molecular Weight : 7,229 Da.
  
  
• Solubility in : well in water and saline.
  
  
• Purity min. : salt-free, freeze-dried preparation; homogeneous (CM-cellulose & gel-chromatography).
  
  
• Biological Activity : nicotinic receptor antagonist, with a reversible binding to the receptor (its affinity is 1/40th that of Erabutoxin b).
  binding to the acetylcholine receptors of Torpedo marmorata electric organs:
  Kd = 1.6 x 10-9 M. (3)
  
  
• Toxicity (LD₅₀) : mice (i.m.): 0.85 mg/kg. (2)
  
  
• Storage recommendations : stable in freeze-dried state; keep in dark and cold place; in solution, keep at -20 °C.
  
  
• CAS Reg. No. : 75433-28-2
  
  
• Bibliography :
  
  1. Tamiya et al., "Studies on sea-snake venoms: crystallization of Erabutoxins a and b from Laticauda semifasciata venom." Biochem. J. (1966). 99:624-630
  2. Ishikawa et al., "Structures of snake toxins and their affinity to the acetylcholine receptor of fish electric organ." Toxicon (1977). 15:477-488
  3. Chiappinelli et al., "The effects of a- and b- neurotoxins from the venoms of various snakes on transmission in autonomic ganglia." Brain Res. (1981). 211:107-126
  4. Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451