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ION CHANNEL and RECEPTOR LIGANDS TOXINS & ALKALOIDS

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| | L8113 DENDROTOXIN I
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| ( DTX-I, DPI ) |
a potent blocker of voltage-sensitive K+ channels; also blocks the Ca2+-activated K+ channels; induces GABA release in synaptosomes.
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60-amino acid polypeptide, with 3 disulfide bridges from Dendroaspis polylepis polylepis snake venom.
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| PRICES |
| Quantity | US Dollars | EURO |
100 µg | 191.80 | 137.00 |
5 x 100 µg | 767.20 | 548.00 |
- Molecular Weight : 7,218 Da.
- Solubility in : Soluble in water.
- Purity min. : 97% (HPLC, mass spectrometry).
- Biological Activity : Potent inhibitor of various types of voltage-sensitive K+ channels. Inhibits the K+ channels at the pre and post-synaptic level in the intestinal smooth muscle [1]. It also inhibits Ca2+-sensitive K+ channels from rat skeletal muscle, incorporated into planar bilayers (Kd = 90 nM in 50 mM KCl). DTX-I would not affect the Ca2+ or voltage dependence of gating [3].
Like b-BuTX, it affects neurotransmission at the neuromuscular junction by an interaction with pre-synaptic nerve terminals [2]. Potent convulsant when administered intracerebro-ventricularly [1].
nM ranges induce GABA release from brain synaptosomes [1].
- Toxicity (LD50) : mice (i.p.): > 4 mg/kg.
mice (i.c.): 8 µg/kg.
- Storage recommendations : store in saline.
- CAS Reg. No. : 107950-33-4
- Bibliography :
- Schweitz et al., "Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom." Toxicon (1990). 28(7):847-856
- Rehm et al., "Existence of different populations of the DTXi binding protein associated with neuronal K+ channels." Biochem. and Biophys. Res. Com. (1988). 153(1): 231-240
- Lucchesi et al., "Subconductance behavior in a maxi Ca2+-activated K+ channel induced by Dendrotoxin-I." Neuron, vol. 4, January, 1990.
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Revised : 26/04/2007 10:27 - Copyright © Latoxan |
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